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Flashcards in Repro drugs Deck (48):
1

Leuprolide MOA

GnRH analog
Pulsatile = agonist action
Continuous = antagonist action

2

Pulsatile leuprolide for:

infertility

3

continuous leuprolide for:

prostate cancer, fibroids, precocious puberty

4

Leuprolide AE

Anti-androgens (if continuous), N/V

5

Synthetic estrogens:

ethinyl estradiol, DES, mestranol

6

estrogen use in men:

androgen-sensitive prostate cancer

7

estrogen toxicity:

Endometrial cancer, post-meno bleeding, thrombi, clear cells adenocarcinoma in vagina of kids whose moms took DES. Contraindicated in ER+ breast cancer, or DVT Hx

8

Clomipine MOA

SERM; hypothalamic estrogen receptor antagonist; so prevents feedback inhibition, so increases LH and FSH

9

Clomiphene use

induce ovulation (via LH and FSH surge) in anovulatory states (i.e PCOS)

10

Clomiphene AE

VISUAL DISTURBANCES, hot flashes, ovarian enlargement, multiple simultaneous pregnancies

11

Tamoxifen use/MOA

agonist: uterus and bone
antagonist: breast
use: ER+ treat and prevent recurrence of ER+ /PR+ great cancer

12

Tamoxifen AE

endometrial cancer and thromboembolisms

13

Raloxifen use/MOA

agonist: bone
antagonist: breast and uterus
use: osteoporosis (ER+ prevention)

14

Raloxifen AE

thromboembolisms

15

HRT use

relief of menopausal symptoms (hot flashes, vaginal atrophy), osteoporosis

16

HRT AE

endometrial cancer (add progesterone to decrease risk). Maybe increase CV risk

17

Anastrazole/exemestane MOA/use

aromatase inhibitor (decrease E). Used in post-menopausal ER+ breast CA

18

Progestins MOA and use

MOA = decrease growth and vascularization of endometrium.
Use = OCP, rx of endometrial CA, rx of abnormal uterine bleeding

19

Mifepristone (RU-486) MOA

COMPETITIVE progestin-R inhibitor

20

Mifepristone (RU-486) use

abortions (progesterone keeps pregnancy going, so now you are blocking progesterones receptor)

21

Mifepristone (RU-486) co-drug

misoprostol (PGE1) - PG sensitize endometrium to the drug

22

Mifepristone (RU-486) AE

heavy bleeding, N/V/anorexia, abdominal pain

23

Combined OCPs: components

estrogen + progestins

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Combined OCPs MOA

E and P in pill feedback to inhibit LH and FSH. no LH/FSH = no E surge = no LH surge = no ovulation.

Progestins also thicken cervical mucus and inhibit endometrial proliferation

25

Combined OCPs contraindications

SMOKERS >35, TE/stroke Hx, ER+ tumour hx

26

Terbutaline

b2 agonist to relax uterus; used to stop contractions frequency in labour

27

Ritodrine

b2 agonist to relax uterus; used to stop contractions frequency in labour

28

Danazol MOA

partial agonist at androgen-Rs (synthetic androgen)

29

Danazol use

endometriosis, HEREDITARY ANGIOEDEMA

30

Danazol toxicity

weight gain, edema, hirsutism, masculinization, acne, lowers HCL, hepatotoxicity

31

Testosterone/methyltestosterone use

hypogonadism, promotes 2' sex characteristiics, ANABOLISM post-burn or injury

32

Testosterone/methyltestosterone toxicity

masculinize females. testicular atrophy. premature EPIPHYSEAL PLATE CLOSURE. increase LDLs and decrease HDLs

33

Finasteride MOA

5a-reductase inhibitor

34

Finasteride use

male-pattern baldness and BPH (can actually decrease side of prostate)

35

Flutamide MOA

NON-steroidal competitive inhibitor @ androgen-Rs

36

Flutamide use

prostate CA

37

Ketoconazole MOA

inhibits 17,20-desmolase; stops steroid synthesis

38

Spironolactone MOA

inhibits 17,20-desmolase and 17-a-hydroxylase; stops steroid synthesis

39

Ketoconazole use

PCOS to reduce androgenic symptoms

40

Ketoconazole AE

Gynecomastia and amenorrhea

41

Spironolactone use

PCOS to reduce androgenic symptoms

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Spironolactone AE

Gynecomastia and amenorrhea

43

Tamsulosin MOA and use

a1-A and a1-D selective a1-antagonists, found specifically on the prostate. inhibit smooth muscle contraction to relieve PBH symptoms (does NOT decrease prostate size like finasteride)

44

PDE-5 inhibitors:

sildenafil, vardenafil, tadalafil

45

sildenafil, vardenafil, tadalafil MOA

PDE-5 inhibitors = increased cGMP = VD corpus cavernosum = bonerrrr

46

sildenafil, vardenafil, tadalafil AE

headache, flushing, DYSPEPSIA, CYANOPSIA (see blue tint). Absolute contraindication with nitrates!!

47

Minoxidil

Direct arteriolar VD

48

Minoxidil use

androgneic alopecia, severe refractory HTN