NEURO - Glaucoma Flashcards Preview

DRUGS > NEURO - Glaucoma > Flashcards

Flashcards in NEURO - Glaucoma Deck (24):
1

Accommodation receptor and muscle

M3 - ciliary

2

Miosis receptor and muscle

M3 - sphincter pupillae

3

Mydriasis receptor and muscle

a1 - Radial muscle (dilator pupillae)

4

Increase aqueous humour production receptor

b2

5

Decrease aqueous humour production receptor

a2

6

alpha agonists for glaucoma

Epinepherine (a1)
Brimonidine (a2)

7

Epinephrine MOA

a1 vasoconstriction causing decreased aqueous humour production

8

Epinephrine AE

Mydriasis (a1), so CANNOT use for closed-angle glaucoma

9

Brimonidine MOA

a2 agonist decreasing aqueous humour production

10

Brimonidine AE

a2 agonist (decrease sympathetics), so causes:
blurry vision
ocular hyperemia
Foreign-body sensation
ocular allergic reactions
ocular pruritus

11

beta-blockers for glaucoma

timidol
betaxolol
carteolol

12

b-blockers in glaucoma MOA

decease aqueous humour production

*No pupillary/vision changes because that is via M3 and a1

13

Diuretics in glaucoma

Acetazolamide

14

acetazolamide MOA

inhibit CA, which decreases aqueous humour production

*No pupillary/vision changes because that is via M3 and a1

15

Cholinomimetics in glaucoma

Direct: pilocarpine, carbachol

Indirect: physostigmine, chothiophate

16

Direct cholinomimetic MOA

pilocarpine, carbachol

Contract ciliary muscles (M3) to open trabecular meshwork and increase aqueous humour outflow

17

Cholinomimetics in glaucoma AE

Miosis (another action via M3, but via sphincter pupillae)
Cyclospasm (via ciliary contraction)

18

Indirect cholinomimetic MOA

Physostigmine, echothiophate

Physostigmine for emergencies - very effective opener of canal os schlemm

19

Prostaglandins in glaucoma

Latanoprost (PGF-2a)

20

Latanoprost MOA

PGF-2a, increases outflow of aqueous humour

21

Latanoprost AE

Darkening (browning) of iris

*used off-label for eyelash growth*

22

Glaucoma treatment contraindicated in closed-angle glaucoma

epinepherine (because of mydriasis)

23

glaucoma rx causing iris browning

latanoprost

24

glaucoma rx that won't affect vision/accomadation

beta-blockers or acetazolamide