Anti-cancer Flashcards Preview

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Flashcards in Anti-cancer Deck (60):
1

6-MP activation

HGPRT

2

6-MP breakdown

XO

3

6-MP toxicity

myelosuppression, hepatotoxicity (hepatitis and cholestasis)

4

Increase 6-MP toxicity via:

alloputinol or febuxostat (block XO)

5

6-MP MOA

Purine analog

6

Cladiribine MOA

purine analog

7

Rx of Hairy cell

Cladribine

8

Cladribine toxicity

myelo, nephrotoxicity, neurotoxicity

9

Cytarabine MOA

pyrimidine analog

10

Cytarabine AE

panCYTopenia (leuko, thrombo, megaloblastic anemia)

11

5-FU MOA

pyrimidine analog; inhibits thymidilate synthase

12

Purine analogs

6-MP, azathioprine, cladribine

13

pyrimidine analogs

cytarabine, 5-FU

14

Leucovorin: when it works and doesn't work

works for MTX; does NOT work for 5-FU (actually potentiates it)

15

MTX MOA

folic acid analog; competitively inhibits DHF reductase

16

MTX Rx

cancers: leukemiaa (ALL), lymphomas, chorioCA, sarcomas.
Non-neoplastic: ectopic pregnancy (medical abortion), RA, psoriasis, IBD, vasculitis.

17

MTX AE

myelo (rx = leucovorin), hepatoxoicity, mucocytis, pulmonary fibrosis

18

hydroxyurea MOA

inhibits ribonucleotide reductase

19

S-phase drugs

6-MP, 6-TG, azathioprine, cladribine, cytarabine, 5-FU, MTX, hydroxyurea

20

Anti-tumour ABx

Bleomycin, dactinomycin, doxorubicin, danaurubucin

21

Bleomycin MOA

Free-radical -> DNA strand breaks

22

Bleomycin AE

Pulmonary fibrosis, skin hyper pigmentation, mucocytis, *MINIMAL myelosuppresion

23

Doxo/daunorubicin MOA

Intercalates into DNA -> breaks + free radicals

24

doxo/daunorubicin AE

dilated cardiomyopathy, alopecia

25

doxo/daunorubicin AE Rx

Dexrazoxane

26

Dactinomycin MOA

intercalates

27

Dactinomycin use

Child tumours (wilms, ewing, rhabdomyosarcoma)

28

akylating agents act on what stage of cell cycle?

G1

29

Name all alkylating agents

Busulfan, cycloforfamide, isofosfamide, nitrosureas (___mustanes + streptozocin)

30

Busulfan MOA

cross-links

31

busulfan AE

pulmonary fibrosis , hyperpigmentation

32

busulfan use

CML and ablating pt bone marrow before transplant

33

cyclophosphamide/isoforphamide MOA

cross-links @ G-N7

34

cyclophosphamide/isophosphamide AE + Rx

hemorrhagic cystitis; prevent/rx with mesna

35

nitrosureas (___mustines + streptozocin MOA/use

Bioactivated, cross BBB, crosslink DNA. BBB .: rx brain tumours (i.e. GBM)

36

nitrosureas (___mustines + streptozocin AE

CNS effects (confusion, dizzy, ataxia)

37

paclitaxel MOA

hyperstabilize polymerized MTs .: prevent anaphase

38

paclitaxel AE

myelo, alopecia, hypersensitivity

39

vincristine/vinblastin MOA

inhibit b-tubulin polymerization

40

vincristine AE

neurotoxicity (areflexia, peripheral neuritis, paralytic ileus)

41

vinblatine AE

myelosuppression

42

cisplatin/carboplatin MOA

crosslink DNA

43

Cisplatin/carboplatin AE and Rx

Ototoxicity and nephrotoxicity (prevent with amifortine (free radical scavenger) and chloride saline diuresis

44

etoposide/teniposide MOA

inhibit topo II --> DNA degradation

45

irinotecan/topotecan

inhibit topo I (prevent unwinding and replication)

46

Bevacizumab MOA and AE

MOA = VEGF; AE = bleed, clot, impaired wound healing

47

Erlotinib

MOA = EGFR

48

Imatinib MOA

tyrosine kinase of Bcr-Abl and c-kit

49

imatinib AE

fluid retention

50

Rituximab MOA

CD20 (so all non-hodgkin lymphomas)

51

Rituximab AE

PML

52

Tamoxifen MOA

Antagonist: breast
Agonist: endometrium, bone

53

Tamoxifen use:

breast cancer prophylaxis AND treatment

54

Raloxifen MOA

Antagonist: breast and endometrium
Agonist: bone

55

Raloxifen use:

breast cancer prophylaxis ONLY, OP prevention

56

Traztuzumab MOA/use

HER-2-nu (c-erb-B2) antibody.
Her-2-nu breast cancer and gastric cancer

57

HER-2-nu mechanism

tyrosine kinase receptor

58

Traztuzumab AE

Cardiotoxicity

59

Vemurafenib MOA

small molecule inhibitor of BRAF

60

Vemurafenib use

Malignant melanoma