Cell- material interaction

Question 1

Describe how cells bind to materials

Answer 1

• Cells do not bind to the material or see the material as an ECM.
• However if a biomaterial contains proteins that have been absorved the cells are able to form focal adhesions via intergrins and bind to the proteins

Question 2

List the proteins that cells van bind to on a material surface

Answer 2

1) Collagen
2) FN
3) Laminin
4) Vitronectin

Question 3

What happens when the cells form focal adhesions via intergrins

Answer 3

The cell spreads

Question 4

Describe the affects of different functional groups

Answer 4

• Different functional groups affect protein adsorption

Question 5

Hydrophylic vs Hydrophobic

Answer 5

Hydrophylic - less protein adsorption
Hydrophobic - More protein adsorption

Question 6

Nanotopgraphy

Answer 6

larger = more focal adhesion

Question 7

stiffness

Answer 7

more stiff = more focal adhesion
less stiff = less focal adhesion