Cephalosporins and Carbapenems Flashcards Preview

POD Exam II > Cephalosporins and Carbapenems > Flashcards

Flashcards in Cephalosporins and Carbapenems Deck (26):
1

Cephalosporin MOA:

Binds to PBPs, inhibits crosslinking of peptidoglycan strands.

2

Cephalosporins for meningitis:

3rd Generation
- Ceftriaxone (4x normal dose).

3

Cephalosporins that are hepatically eliminated (2):

- Ceftriaxone
- Cefoperazone

4

Cephalosporins ADR (7):

- Hypersensitivity reaction.
- Bleeding.
- Cefamandole and cefoperazone.
- Disulfiram-like intolerance (alcohol).
- Diarrhea.
- Pseudomembranous colitis.
- Interstitial nephritis.
- Serum sickness (cefaclor).

5

Cephalosporin drug interactions (3):

- Warfarin.
- Alcohol.
- Probenecid.

6

First generation cephalosporins (2):

PO:
- Cephalexin
IV:
- Cefazolin

7

Second generation cephalosporins (3):

PO/IV:
- Cefuroxime
IV:
- Cefoxitin (cephamycin)
- Cefotetan (cephamycin)

8

Third generation cephalosporins (2):

IV:
- Ceftriaxone
- Ceftazidime

9

Fourth generation cephalosporins (1):

IV:
- Cefepime

10

Fifth generation cephalosporins (1):

IV:
- Ceftaroline

11

First generation cephalosporins spectrum of activity:

G+:
- Staph, strep
G-:
- PIddly, E. Coli

12

Second generation cephalosporins spectrum of activity:

G+:
- Staph, strep
G-:
- Piddly, PEK
Anaerobes (cephamycins only)

13

Third generation cephalosporins spectrum of activity:

G+:
- Strep
G-:
- SPACE

14

Fourth generation cephalosporins spectrum of activity:

G+:
- Staph, strep
G-:
- SPACE

15

Fifth generation cephalosporins spectrum of activity:

G+:
- Staph, strep, enterococcus
G-:
- SCE

16

Cephalosporin indicated for community acquired pneumonia:

3rd generation

17

Cephalosporin indicated for nosocomial pneumonia:

- Ceftaz
- Cefepime

18

Cephalosporin indicated for meningitis:

Ceftriaxone

19

Cephalosporin indicated for surgical prophylaxis:

- Cefazolin
- Cephamycins for abd/GI surgeries

20

Cephalosporin indicated for febrile neutropenia:

- Ceftaxidime
- Cefepime

21

Carbapenems (4):

D.I.M.E.
- Doripenem
- Imipenem
- Meropenem
- Ertapenem

22

MOA of carbapenems:

Bind to PBP resulting in cidal effect.

23

ADRs for carbapenems (5):

- Seizures
- Cross allergenicity w/ PCN
- Anemia
- Leukopenia
- Thrombocytopenia

24

Carbapenem D.I.M. spectrum of activity:

- Staph, Strep
- SPACE
- Anaerobes
- ESBL PEK

25

Ertapenem spectrum of activity:

- Staph, strep
- Anaerobes
- ESBL PEK

26

Aztreonam:

- G- coverage onmly