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Flashcards in Penicillins Deck (18):
1

Penicillin MOA:

Inhibit bacterial cell wall synthesis.
- Blocks crosslinking of adjacent peptidoglycan strands resulting in lysis.
PCN-binding proteins (PBPs) are targets of Beta-lactam antibiotics.
- Peptidoglycan transpeptidase.

2

PCN most important route of elimination:

Renal excretion.
- High concentrations in the urine.

3

PCN absorption:

Food delays and decreases absorption.
- Except amoxicillin, Pen V and carbencillin.

4

PCN in brain:

Poor distribution to brain and CSF (unless inflammation present).
- Insoluble in lipid.

5

Most common hypersensitivity reaction:

Maculopapular rash on abdomen/trunk.

6

Adverse effects of methicillin:

Interstitial nephritis.

7

Uses for Pen G/VK:

Gram positive organisms:
- Staph - 99% resistant.
- Strep pneumoniae resistance.
- Gonorrhea resistance occurring.

8

Anti-Staph PCNs (5):

IV:
- Methicillin
- Oxacillin
- Nafcillin
PO:
- Cloxacillin
- Dicloxacillin

9

Aminopenicillins (2):

- Ampicillin
- Amoxicillin

10

Aminopenicillins spectrum of activity (8):

Strep, enterococcus, piddly, PEK:
- Streptococcus.
- Enterococcus (drug of choice).
- Haemophilus.
- Salmonella.
- Shigella.
- Proteus.
- E. Cola.
- +/- Klebsiella.

11

Carboxypenicillins (2):

- Carbenicillin (not made anymore).
- Ticarcillin

12

Spectrum of activity for carboxypenicilins (4):

- Streptococcus.
- G- piddly.
- G- PEK.
- G- SPACE (pseudomonas req's high concentrations).

13

ADRs for carboxypenicillins (3):

- Hypersensitivity.
- Platelet dysfunction (dose dependent).
- Na+ overload.

14

Ureidopenicillins (2):

- Mezlocillin
- Pipercillin

15

Ureidopenicillins spectrum of activity (5):

- Bacteriodes fagilis.
- Streptococcus.
- Enterococcus.
- G- PEK
- G- SPACE

16

Beta-lactamase inhibitors add coverage to (2):

- Staphylococcus
- Anaerobes

17

ADRs for aminopenicillins (2):

- Hypersensitivity
- Diarrhea
- Take with food to decrease symptoms.

18

Complication with ticarcillin:

Na+ load.