Quinolones and Tetracyclines Flashcards Preview

POD Exam II > Quinolones and Tetracyclines > Flashcards

Flashcards in Quinolones and Tetracyclines Deck (11):
1

Quinolones MOA:

Inhibit bacterial DNA gyrase and topoisomerase IV.
- PAE
- Bactericidal

2

Quinolones (5):

- Ciprofloxacin.
- Ofloxacin.
- Levofloxacin.
- Moxifloxacin.
- Gemifloxacin.

3

Quinolones ADRs (10):

- Hypersensitivity.
- Photosensitivity.
- Neutropenia.
- Eosinophilia.
- QT prolongation.
- N/V/D.
- Interstitial nephritis.
- CNS, especially in elderly and AKI.
- Arthropathy (< 18 yrs).
- Tendon rupture (> 60 yrs).

4

Quinolones drug interactions (3):

- Ciprofloxacin can 2x theophylline levels.
- Antacids/iron/sucralfate/multivitamins - wait 2-4 hours.
- Warfarin: Increased INR.

5

Quinolones spectrum of activity:

G+ (except cipro and ofloxacin)
G-:
- Cipro/Levo SPACE
- Moxi SACE
Anaerobic: Moxi
Atypicals: Levo/Moxi/Cipro cover CML

6

Quinolone that does NOT cover UTIs:

Moxifloxacin.

7

Tetracyclines (6):

- Doxycycline.
- Minocycline.
- Demeclocycline.
- Oxytetracycline.
- Chlortetracycline.
- Tetracycline.

8

Tetracycline MOA:

Reversibly binds to 30S ribosomal subunit.
- Bacteriostatic.
- Absorption increased by food.

9

Tetracycline ADRs (5):

- Photosensitivity.
- Discoloration of developing teeth (during pregnancy - 8 yrs old).
- Reversible DI (demeclocycline).
- Vestibular side effects (minocycline).
- Fanconi-like syndrome.
- N/V, lethargy, polydipsia, polyuria, proteinuria, acidosis, hypokalemia.
- Expired citric acid formulation.

10

Tetracycline drug interactions (2):

- Decreased absorption when co-administered with cations, antacids, dairy products.
- Enhances warfarin. Increased PT/INR.

11

Tetracycline spectrum of activity:

- Gram +
- Gram -
- Atypicals
- Rickettsia (drug of choice)