Flashcards in CF Deck (7)
What is the mutation that causes of CF?
What is the cause of this mutation?
deletion of delta508 in CFTR gene on chrom 7q
defective CFTR Cl- channel
How does a baby with CF present?
-meconium illius (no abnormalities with GI tract, poop just gets stuck due to super viscous pancreatic secretions)
-failure to thrive
What causes all the problems in CF?
thick mucous secretions createes plugs in lungs, pancreas, and liver
What problems do CF pts have?
chronic bronhcitis --> bronchiectasis
pancreatic insufficiency --> FATTY REPLACEMENT
fat soluble vitamin def
infertility in men
How is CF diagnosed?
high Cl- conc in sweat test
What pneumonia is assc with CF?
pneudomonas and s.aureus