Flashcards in CF Deck (7):
What is the mutation that causes of CF?
What is the cause of this mutation?
deletion of delta508 in CFTR gene on chrom 7q
defective CFTR Cl- channel
How does a baby with CF present?
-meconium illius (no abnormalities with GI tract, poop just gets stuck due to super viscous pancreatic secretions)
-failure to thrive
What causes all the problems in CF?
thick mucous secretions createes plugs in lungs, pancreas, and liver
What problems do CF pts have?
chronic bronhcitis --> bronchiectasis
pancreatic insufficiency --> FATTY REPLACEMENT
fat soluble vitamin def
infertility in men
How is CF diagnosed?
high Cl- conc in sweat test
What pneumonia is assc with CF?
pneudomonas and s.aureus