CGRP and Migraine Flashcards Preview

392 > CGRP and Migraine > Flashcards

Flashcards in CGRP and Migraine Deck (5):
1

features of migraine that make it a compelling drug target

• Common disorder
• Severe/disabling symptoms
• High annual cost
• Treatments options are limited/ineffective
• Large potential market
• Robust targets for drug development

2

List two advantages of using a monoclonal
antibody to treat migraine.

Safe or proteins that a broken down naturally or don’t cause liver
toxicity
• Fail early due to poor efficacy
• Long lasting or have Very slow clearance
• Good as a preventative or prophylactic

3

List two disadvantages of using a monoclonal
antibody to treat migraine.

•Very expensive (Estimated $8000-$25000)•Difficult to administer (injections)•Slow distribution (are slow to enter tissues and typically don’t enter the brain)•Very slow clearance*

4

Challenges targeting CGRP in migraine

No rodent models for migraine
Telcagepantrequires high doses (low bioavailabilty_)

5

Challenges targeting CGRP in migraine

No rodent models for migraine
Telcagepantrequires high doses (low bioavailabilty_)
Olcegepantis not bioavaliable
Telcagepantterminated due to safety