CH 9 afd avd apd Flashcards Preview

MicroBiology > CH 9 afd avd apd > Flashcards

Flashcards in CH 9 afd avd apd Deck (17):
1

antifungal drugs

-often toxic to the host
-fungal detoxification systems inactive drug

-target cell walls (chitin) and membrane sterols--bind to cell membrane and decrease fluidity, block membrane sterol syn., interact with chitin synthase

2

Fungal Infections

-superficial (tpical) mycoses--athelete's foot, candidiasis
-subcutaneous (just under skin) mycoses--sporotrichiosis, rose-handler's disease

-systemic (spreads throughout body) mycoses--often initiate in the lungs, frequently opportunistic infections

3

antiviral drugs (AVD)

-Disrupt critical stages of viral life cycle
-block syn. of viral-specific nucleic acids

-difficult to use drug therapy since viruses use host's cell machinery

4

AVD-Acyclovir

targets viral DNA polymerase, high selective toxicity, herpes, chicken pox, shingles

5

AVD-Vidarabine

-targets viral DNA polymerase
-herpes, chicken pox, shingles

6

AVD-Amantadine and rimatadine

-Influenza A
-Blocks uptake of virus

-Parkinson's disease

7

AVD-Tamiflu and Relenza

Block release of virus

8

AVD-Cidofovar

Broad-spectrum antiviralBlocks assembly of viruses

9

AVD- Azidothymine (AZT)

Targets reverse transcriptase

10

AVD-HIV drugs

-nucleoside reverse transcriptase inhibitors
-non-nucleoside RT inhibitors

-protease inhibitors--block assembly

-fusion inhibitors--block entry (only works on virus with a envelope)

11

AVD-Viral resistance

-viruses can develop resistance to AVD
-H1N1 resistant to Tamiflu

12

Antiprotozoan Drugs (APD)

-Mechanism of action for most drugs in not well understood--target NA, inteference with ETC, block RNA function, interfere with metabolic pathways-often have significant side effects, since they are eukaryotic the drugs affect humans as well, must find drugs specific to protozoan

13

APD-Quinine drugs

-Chloroquine, qualaquin
-treatment of malaria

14

APD-Artemisinin

-sweet wormwood

15

APD-Metronidazole

treatment of entamoeba infections

16

APD-Aminoglycosides

interfere with RNA function

17

APD-Atovaquone

-Blocks ETC
-Toxoplasmosis

-Penumocystis pneumonia