Ch.23: Beta Blockers (Swift) Flashcards Preview

Pharmacology > Ch.23: Beta Blockers (Swift) > Flashcards

Flashcards in Ch.23: Beta Blockers (Swift) Deck (15):
1

where are B1 receptors found?

cardiac m.

2

where are B2 receptors found

bronchial and vascular smooth m. Some in myocardium

3

stimulation of B receptors leads to:

increase in contractility, SA node discharge rate and AV node conduction

4

stim. of B2 receptors leads to:

-increase SA node discharge rate, AV node conduction
-bronchodilation

5

effects of beta blockade

-decrease SA node firing rate --> decr. HR, improved myocardial perfusion
-slowed AV node conduction
-dec. myocardial contractility --> less myocardial O2 consumption

6

uses of beta blockers**

-anti-arhythmic (esp. for SVTs and VTs)
-hypertrophic cardiomyopathy
-CHF when active heart failure is resolved**

7

side effects of beta blockers

-bronchospasm
-bradycardia, AV block, neg. ionotropic effect
-depression, lethargy, insomnia

8

is propanolol selective?

No. Therefore, creates greater decrease in HR than other B-blocers

9

is atenolol selective?

yes, for B1

10

propanolol lipid or water soluble?

lipid

11

atenolol lipid or water soluble?

water

12

rank duration of action of propanolol, esmolol, and atenolol*

atenolol > propanolol > esmolol

13

main use of esmolol

acute anti-arrhythmic agent for SVTs

14

is sotalol selective?

no

15

how does sotalol work?

blocks K channels