chap 3

Question 1

phospholambane

Answer 1

Inhib SERCA-2 (muscles cardiaques/squelettiques lents)

Question 2

sarcolipine

Answer 2

Inhib SERCA-2 (muscles squelettiques RAPIDES)

Question 3

w-agatoxin, w-conotoxin, a2s ligands

Answer 3

régulation/modulation canaux Ca

Question 4

gabapentine, prégabaline

Answer 4

SNC : a2s = baisse influx Ca = baisse transm glumate => Anti-Epilepsie
ME : a2s1 (Cav2 pre-synapse) = baisse Ca = baisse exocytose SP et glutamate = Analgésique

Question 5

Cav 1.1

Answer 5

Muscles squelettiques

Question 6

Cav 1.2

Answer 6

Muscles cardiaque et lisses

Question 7

Cav 1.3

Answer 7

Noeud sinusal, noeud A-V, neurones, cellules endocrines

Question 8

Cav 1.4

Answer 8

Rétine

Question 9

Dihydropyridines (Nifédipine)

Answer 9

Bloqueurs Cav1.2
Relaxation vasculaire (HTA) = muscles lisses

Question 10

Phénylalkylamine (Vérapamil)

Answer 10

Bloqueurs Cav1.2
= Antiarythmique, Antiangoreux
miscles lisses et noeud A-V

Question 11

Benzothiazépine (Diltiazem)

Answer 11

Bloqueurs Cav1.2
Antiagoreux
muscles lisses

Question 12

Cav2.1

Answer 12

Ouverture volt modéré
Inactivation lente
Neurones (pré-synaps) + exocytose NM
activés PKA

Question 13

Cav2.2

Answer 13

Ouverture Haut Volt
Inactivation rapide
Neurones (pré-synaps) + exocytose NM
activés PKA

Question 14

ziconotide

Answer 14

ferme Cav2.2 (n. sensitifs) = Antalgésique intrarachidien

Question 15

Caféine

Answer 15

Inhib R-IP3 (expérimentale)

Question 16

RY1 : muscles squelettiques

Answer 16

Ach = R-nico = Dépoly = Cav1.1 actif = Ouvre RY1 = Augm. Ca cyt = Contraction

Question 17

dantrolène

Answer 17

Inhib RY1 = Baisse Ca cyt = Anti-Spastique (Sclérose en plaque SEP)

Question 18

EF-hand

Answer 18

calmoduline = 4
MLCK
CaM kinase

Question 19

Domaine C2

Answer 19

PKC
PLC
cPLA2

Question 20

Annexine 1 = Lipocortine 1

Answer 20

Inhib PLA2 = Baisse messagers inflammatoires (acide arachidonique, prostaglandines)

Question 21

Glucocorticoïdes (Prédnisone, Prédnisolone)

Answer 21

Active synt de Lipocortine 1 = Anti-inflammatoire
Inflammation chronique/aigue
Réaction allergique

Question 22

Noeud sinusal : Fct cardiaque

Answer 22

Dépoly : Cav 1.3
Repolt : Kv
Dépoly : HCN, Kach
= Chronotrope (frq cardiaque)

Question 23

Cardiomyocytes : fct cardiaque

Answer 23

Dépoly : Nav
Plateau dépoly : Cav 1.2
Repolt : Kv
vidange Ca (Serca/PMCA)
= Inotrope (force cardiaque)

Question 24

Synaptotagmines

Answer 24

Domaine C2
Exocytose

Question 25

Troponine C

Answer 25

Interaction myosine-actine = CONTRACTION

Question 26

Parvalbumine

Answer 26

Séquestre Ca ds cyt = PAs CONTRACTION = régulation

Question 27

Calséquestrine

Answer 27

Séquestre Ca ds RE = PAs CONTRACTION = régulation

Question 28

Ca, calmoduline ds glycogénolyse

Answer 28

Augm. Ca cyt = Ca-CAM = Activ Phosporylase K = Glycogène en Glucose

Question 29

Ca ds Contraction

Answer 29

Ouvert Cav 1.2/R-IP3 => Augm. Ca = Ca-CAM = MLCK active = MLC-P CONTRACTION

Question 30

2 effets Ca ds Inflammation

Answer 30

- Active Lipocortine 1 = Anti-infla - Active domaine C2 de cPLA2 = Inflammatoire