Flashcards in Chapter 10: Hospital-Acquired Gram-Negatives Deck (14):
What are the Hospital-acquired infections?
Wind: Penumonia - ventilation, intubation
Water: UTI - Foley
Wires: bloodstream infection - intravenous
What are the 4 often highly resistant gram-negative bacteria?
Pseudomonas, Acinetobacter, Stenotrophomonas and Burkholderia
obligate aerobic (non-lactose fermenter)
Produces pyoverdin (green pigment) and pyocyanin (blue pigment)
Exotoxin A: like diphtheria toxin
What are the Pseudomonas aeruginosa infections?
External Malignant otitis media
Most ______ pts have their lungs colonized with Pseduomonas aeruginosa. What do these pts develop?
Who is highly susceptible to peumonia caused by Pseduo aeruginosa?
Chronic pneumonia which progressively destroys their lungs
Who have an increased risk of osteomyelitis (related to wounds) due to Pseudomonas aeruginosa?
Diabetic pts: Foot ulcers infected, infection penetrates into bone
IV drug abusers: vertebrae or clavicle
Children: puncture wounds to foot wearing tennis shoe
How does Pseudomonas aeruginosa lead to sepsis?
Infected "wires" or catheters, or from burn-wounds, water, wind etc
What are frequent causes of right heart valve endocarditis in IV drug abusers?
Malignant external otitis
Pseudomonas external ear canal infection burrows into the mastoid bone
Primarily in elderly diabetic pts
Oxidase-positive aerobic gram-negative bacillus
Virulence: Extremely antibiotic resistant
Grow in water, soil, plants, animals
Infection in burn and ventilated pts
Who has the greatest risk for Burkholderia cepacia?
Asymptomatic carriage, bronchiectasis (dilated infected airways) or rapidly progressive pneumonia with bacteremia
Part of normal respiratory flora
Can cause pneumonia, line-related bacteremia
Virulence: extremely antibiotic resistant
Virulence: multiple acquired mechanisms of antibiotic resistance
Aerobic gram-negative bacteria
Soil and water