Flashcards in Chapter 12: Yersinia, Francisella, Brucella, and Pasteurella Deck (13):
What do Yersinia, Francisella, Brucella, and Pasteruella have in common?
All gram - rods
Very virulent, able to penetrate any body area or be inhaled
Facultative intracellular organisms: migrate to regional LN, set up infection, move to bloodstream and other organs (liver, spleen, lungs)
Yersinia pestis causes what?
the bubonic plague
Virulence: F1 (capsular), V and W resist destruction after phagocytosis
What are the symptoms of the bubonic plague?
Nodes swell like eggs and become hot, red, and painful
Fever and headache
Hemorrhages under the skin ->blackish discoloration
What does Francisella tularensis cause?
Tularemia: disease that resembles bubonic plague
Ulceroglandular and pneumonic diseases
Oculoglandular tularemia (eyes)
Typhoidal tularemia (GI tract)
Transmission of Fracisella tularensis?
Rabbits, ticks and deerflies
After a bit from an infected rabbit, tick or deerfly a well-demarcated hole in the skin with a black base develops
Fever and systemic symptoms develop
Local LN swell, red, painful
Aerosolization of bacteria during skinning and evisceration of an infected rabbit or hematogenous spread from the skin to the lungs can lead to a lung infection
What are the Brucella species?
based on the animals they infect:
Brucella melitensis (goats)
Brucella abortus (abortion in cows)
Brucella suis (pigs)
Brucella canis (dogs)
Transmission of Brucella to humans
Direct contact with infected animal meat or aborted placentas or ingestion of infected milk products
Pts most likely a worker in meat-packing industry, a veterinarian, farmer or traveler who drinks milk
How does Brucella cause disease?
Penetrates the skin, conjuctiva, lungs, or Gi tract
Lymphatic spread, faculative intracellular growth in Mo, and blood and organ invasion
What are the symptoms of Brucellosis ?
Systemic with fever, chills, sweats, loss of appetite, backache, headache, and sometimes lymphadenopathy
Fever peaks in the evening and slowly returns to normal by morning (Undulant fever)
Symptoms lasts from months to years
Gram - zoonotic organism but is NOT a facultative intracellular organism
Colonizes the mouths of cats