Flashcards in Prions Deck (9):
Kuru: syndromes, etiology, duration til death
Ataxia, myoclonus then dementia
sCJD, fCJD, iCJD
demetia, myoclonus, then ataxia
Unknown, inherited, and infectious
1 to a few years
Psychiatric changes, ataxia, demetia
Months to few years
Sleep disturbances and then demetia
ataxia followed by dementia
All vCJD cases have what DNA similarities?
All of the vCJD cases were homozygous for a methionine at codon 129 for the PRNP gene
What is the gold standard to test for a prion disease?
Histopathologic examination and staining for PrPSc in brain tissue
What are the two forms of PrP protein and what populations generally express each?
PrPc = cellular = normal populations
PrPSc = scrapie = disease state