Chapter 11 Second Half Flashcards Preview

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Flashcards in Chapter 11 Second Half Deck (95):
1

What is relative polycythemia?

Decreased plasma

2

What is absolute primary polycythemia?

Increased total RBC mass

3

What is absolute secondary polycythemia?

Increased Erythropoietin (EPO)

4

Reactive leukocyte disorders are caused by what?

Microbial infection

5

Neutropenia is associated with what?

Aganulocytosis

6

Less than how many cells results in nurtopenia ?

500

7

Agranulocytosis =

Sever neutropenia (<100 cells):

8

How do you diagnose mono>?

Mono spot test

9

What are the classic symptoms of mono?

Reactive lymphocytes, lymphadenitis, fever, splenomegaly, hepatitis

10

"Atypical lymphocytes" are associated with what condition?

Mono

11

In developing countries mono mostly affects _______and is________

Children, asymptomatic

12

In developed countries mono normally affects _______and is most commonly________

Adolescent, symptomatic

13

Mono is transmitted via who?

Saliva

14

What causes cat scratch fever?

Bartonella henselae

15

Most causes (90%) of cat scratch disease are found in who?

Pediatrics

16

Irregular stellar necrotizing granulomas are associated with what condition?

Cat scratch disease.

17

How long does cat scratch disease last?

2-4 months

18

What are 3 lymphoid neoplasms?

Non-Hodgkin lymphoma, Hodgkin lymphoma, multiple myeloma

19

What are 3 myeloid neoplasms?

Acute myeloid nous leukemia, myelodysplastic syndromes, chronic myeloprolifferative disorders

20

What is a Wbc cancer that involves the marrow or blood?

Leukemia

21

What is a WBC cancer that involves that lymphatic tissues?

Lymphoma

22

What is an agressive cancer of lymphoblasts?

ALL

23

Pre B cell ALL affects what?

Marrow/peripheral blood (MC form)

24

The Pre T cell ALL affects what?

Thymus

25

What is the most common type of leukemia in children?

Acute lymphoblastic leukemia (ALL)

26

Pancytopenia is seen in what you of leukemia ?

Acute lymphoblastic

27

Most people are diagnosed with ALL at what age?

4

28

What is the treatment for ALL ?

Chemo (80% cured)

29

What type of cancer is associated with both B and T cells?

Acute lymphoblastic leukemia

30

Chronic lymphocytic leukemia is associated with what cells?

B cells

31

What are general features of acute leukemia?

Stormy onset, marrow suppression, lymphoblasts

32

To be classified as chronic lymphocytic leukemia how may lymphocytes must be present?

4000

33

If there are less than 4000 lymphocytes, CLL will be renamed what?

Small lymphocytic lymphoma

34

What is the most common leukemia of adulthood?

Chronic Lymphocytic leukemia

35

Is chronic lymphocytic leukemia agressive?

No it has a gradual progression

36

CLL involves what?

Blood

37

SLL involves what?

Nodes

38

Suppressed. B cells, hypogammaglobulinemia is associated with what?

Chronic lymphocytic leukemia

39

What is the prognosis for CLL?

Live 4-6 years

40

If chronic lymphocytic leukemia becomes more aggressive it turns into what?

Diffuse large B cell lymphoma

41

Centrocytes are associated with what?

Follicular lymphoma

42

Follicular lymphoma is associated with what cells?

B cell

43

Lymphocytes with a cleaved nuclei are associated with what?

Follicular lymphoma

44

Follicular lymphomas make up what % of adult non Hopkins lymphoma?

40

45

When does follicular lymphoma occur?

>50

46

What are characteristics of follicular lymphoma?

Generalized lymphadenopathy, painless

47

What gene is associated with follicular lymphoma ?

BCL2

48

85% Follicular lymphoma have what?

Translocation on chromosome 14:18

49

What condition is also acted with t(11:14) ? ?>

Mantle cell lymphoma

50

What lymphoma is incurable?

Mantle cell

51

What lymphoma is associated with dysfunctional cyclinS?

Mantle cell

52

What is the most common lymphoma of adulthood ?

Diffuse large B cell lymphoma

53

A history of EBV is associated with what kind of lymphoma ?

Diffuse B cell

54

What kind of lymphoma is commonly extranodal?

Diffuse large B cell

55

If diffuse large B cell lymphoma is seen early where is it most commonly found?>

GI, brain

56

If diffuse large B cell lymphoma is found late where is is commonly found?

Liver, spleen, marrow

57

What kind of lymphoma is also acted with a starry sky pattern?

Burkett lymphoma

58

What kind of lymphoma is assoacted with a mutated MYC gene via t(8:14)

Burkitt lymphoma

59

What kind of lymphoma classically affects African children, usually on the face?

Burkitt lymphoma

60

What is the fastest growing human tumor?

Burkitt lymphoma

61

If Burkitt lymphoma is seen in Africa where does it affect?

Maxilla, mandible

62

If Burkitt lymphoma affects someone in the use where is it seen?

Abdomen, GI, ovaries

63

What is a plasma cell malignant cancer?

Multiple myeloma

64

What 3 things are associated with multiple myeloma?

Osteolytic lesions, neurological, renal failure

65

Punched out lesions, and bence jones proteins are associated with what?

Multiple myeloma

66

What is a treatment for multiple myeloma?

Plasmapheresis, stem cell transplants

67

Where are the top 4 most common sites for multiple myelomas?

Vertebral column, ribs, skull

68

A reed sternberg cell with an owl eye nuclear appearance is associated with what/

Hodgkin lymphoma

69

Hodgkin lymphoma arises from what?

A single cell (spreads to Local lodes)

70

Exposure to agent orange is associated with what?

Hodgkin lymphoma

71

What is associated with an M spike and is incurable?

Multiple myeloma

72

Painless lymphadenopathy and night sweats are associated with what?

Hodgkin's lymphoma

73

Acute myeloid leukemia will replace how much of the bone marrow?

20

74

What percent of myelodysplastic sydromes will transform to AML?

40

75

The Philadelphia chromosome is associated with what leukemia?

Chronic myeloma nous leukemia

76

What kind of leukemia is associated with a t(9;22) ?

Chronic myelogenous leukemia

77

Spent phase or blast crisis is associated with what kind of leukemia ?

Chronic myelogenous leukemia

78

When the red pulp of the spleen has a beef appearance what kind of leukemia do they have?

Chronic myelogenous leukemia

79

Polythemia Vera is also acted with no what?

Increase in EPO (absolute, primary)

80

JAK2 point mutations are associated with what ?

Polythemia Vera

81

Decreased erythropoietin and too may RBC is associated with what?

Polythemia Vera

82

What are symptoms of polycythemia Vera?

Congestion, itching, dysfunctional platelets

83

Wha this associated with MARROW fibrosis ?

Primary myelofibrosis

84

Dacrocytes are also acted with what myeloid neoplasm ?

Primary myelofibrosis

85

Birbeck granules are associated with what?

Histiocytic neoplasms

86

Langerhans cell histo cytosine is common in who?

Less that to year olds

87

Multiform like skin lesions are associated with what?

Multi system langerhans cell histiocytosis

88

What is associated with systemic coagulation, massive tissue injury, crush injuries, and bleeding?

DIC (disseminated intravascular coagulation )

89

What is decreased platelets, possible CNS hemorrhage?

Thrombocytopenia

90

Acute ITP is usually seen in who?

Children

91

Chronic ITP is seen in who?

Reproductive age females

92

What is the most common inherited bleeding disorder?

Von willebrand disease

93

What is autosomal dominant disorder with dysfunctional platelet adherence, causing bleeding guns, easy brushing, epistaxis?

Vin willebrand disease

94

Factor VIII is associated with what?

Hemophilia A

95

Factor IX is associated with what?

Hemophilia B (Christmas disease )