Chapter 16

Question 1

Steps

Answer 1

1. Isotope production
2. Tracer synthesis
3. Injection of tracer into patient
4. Image acquisition
5. Image processing and analysis (diagnosis)

Question 2

Radio pharmaceuticals

Answer 2

Chemical compound is a probe of a specific biological/physiological function

Injected via IV

Question 3

Plan a imaging

Answer 3

Use of gamma camera

Static planar: conventional

Dynamic planar:

Equivalent noise reference

Contrast and resolution

Question 4

SPECT

Answer 4

Tracers: MIBI MDP PERT ECD

Question 5

PET

Answer 5

Technique: takes advantage of unique coincidence gamma radiation in positron-electron annihilation

Teachers: positron emitting isotope of low atomic number

• step 1: produce positron emitting isotopes in cyclotron
• step 2: radiochemistry

Question 6

3 requirements for PET

Answer 6

1. Distinguishing opposed 180 photons from background non positron derived photons
2. Identifying angle of travel
3. Reconstruction of activity distribution

Question 7

Sinogram

Answer 7

Format of coincidence events; gives radial and angular position of annihilation event

Question 8

Image data corrections in PET

Answer 8

Attenuation
Scattering
Normalization
Electronic dead tome

Question 9

Spatial resolution

Answer 9

1. Intrinsic resolution of detectors
2. Scattering of photons in a patient
3. Distance travelled by positrons before annihilation
4. Annihilation photons not emitted in exactly opposite directions

Question 10

Main events in PET

Answer 10

True coincidence events
Single events
Random events