Chapter 16 Endocrine System Flashcards
hormone
steroidal or amino acid-based molecules released to the blood that act as chemical messengers to regulate specific body functions
target cell
tissue cells that have a specific receptor for a hormone
endocrine cell
ductless glands that secrete their hormones into the surrounding tissues
endocrine system
body system that includes internal organs that secrete hormones
neuroendocrine cells
have a neural function and release hormones (hypothalamus)
norepinephrine
A catecholamine neurotransmitter and adrenal medullary hormone, associated with sympathetic nervous system activation
exocrine gland
glands that have ducts through which their secretions are carried to a particular site
amino acid based hormone
most hormones are composed of amino acids; hydrophilic
steroids
synthesized from cholesterol (only gonadal and adrenocortical); hydrophobic
eicosnaoids
leukotrienes: inflammation and allergic reactions
prostaglandins: multiple targets and effects (blood pressure, contractions, pain, etc.)
hydrophilic hormones
all amino acid-based hormones (except thyroid); do not need a carrier protein and act on receptor in the plasma membrane
transport protein
required by steroids and thyroid hormone to move through the blood
free (unbound) hormone
does not have a transport protein; can leave capillary to reach target cell
bound hormone
hormone attached to a transport protein
secondary messenger system
A system of plasma membrane receptors for hormone action (Cyclic AMP & PIP2-Calcium signaling mechanisms)
cyclic AMP signaling mechanism
- Hormone binds receptor
- Receptor activates G protein
- G protein activates adenylate cyclase
- Adenylate cyclase converts ATP to cyclic AMP
- Cyclic AMP activates protein kinases
cAMP
Cyclic AMP; activates protein kinases during cAMP mechanisms
hormone receptor
Acts as the first messenger; hormone causes receptor to change shape
G protein
Activated by receptor; activates an enzyme (such as adenylate cyclase)
effector enzymes
Activated by a G protein; may be stimulated or inhibited depending on the enzyme
amplification effect
when one hormone molecule leads to millions of final product molecules
phosphodiesterase
Intracellular enzyme that degrades cAMP
PIP2-calcium signaling mechanism
- Receptor activates G protein
- G protein activates phospholipase C
- Phospholipase C splits PIP2 into 2 second messengers: diacylglycerol (DAG) and inosital triphosphate (IP3)
- DAG activates protein kinase enzyme; IP3 releases Ca2+
- Ca2+ takes on second-messenger role
phospholipase C
splits a plasma membrane phospholipid called PIP2 into 2 second messengers: diacylglycerol (DAG) & inositol triphosphate (IP3)