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1

what are the cells that express receptors in innate immunity

Macrophages, NK cells, and other cells of innate immunity

2

what is the general property of innate receptors

recognize distinguishable features that recognize microbial vs mammalian cell

3

what are some of the distinguishing features from a microbial vs mammalian cell in innate immunity

carbohydrates, lipids, proteins, and nucleic acids

4

downfall of general property of innate receptors

human cells can carry some same characteristics as fungi, virus, bacteria and parasites

5

receptors: recognize one pathogen specie or many

many

6

why is it so good receptor can recognize multiple pathogenic species

take less receptors to recognize many pathogens

7

how many innate immune receptors

about 100

8

innate cell expresses how many receptors

subset of them

9

why so good cell can express many different receptors

diversity increases the probability that some fraction of the cells will be able to respond effectively to any given pathogen
even if human population has no exposure to

10

what do all body tissues contain

resident macrophages

11

function of resident macrophages

ready to attack any encroaching microorganism, commensal or pathogen

12

what receptors are on resident macrophages

CR1 and CR2 and other receptors

13

CR1 and 2 combine with other receptors on macrophages to do what

work together to bind the invaders and trigger their phagocytosis by macrophage

14

what ligands are recognized by phagocytic receptors

bacterial carbohydrates and lipids

15

lectins

cell surface receptors and plasma proteins that recognize carbohydrates

16

what are the two receptors that are lectins on macrophages

mannose receptor and dectin-1

17

what coordinates the interaction of the carbohydrate ligand with receptors

calcium ion

18

if calcium ion is involved for interaction of carbohydrate with receptors, what are the lectin receptors names

C-type lectins

19

what is the characteristic ligand-binding domain on c-type lectins

c-type lectin domain
CTLD

20

what makes different c-type lectins differ

the number of domains, CTLD

21

dectin-1 has how many CTLD

one

22

Mannose receptor has how many CTLD

8

23

mannose has another carbohydrate recognition domain where?

at amino terminus

24

what binds to other carbohydrate domain in mannose

sulfated galactosamine residues, R-type lectin

25

what are scavenger receptors (SR)

cell surface receptors on macrophages that scavenge damaged molecules of low density lipoprotein from blood

26

what are the two types of SR

SR-A and SR-B

27

what do SR-B recognizes

lipopeptides

28

what do SR-A recognize

lipopolysaccharide (LPS) of gram negative bacteria and the techoic acid of gram positive bacteria
CpG-rich bacterial DNA

29

what do SR-A illustrate about binding to ligands

shows receptors of innate immunity can bind physically similar but chemically different ligands

30

what is a structural feature of several innate immunity receptors

segments of collagen-like triple helix