Cyclophosphamide
Alkylating agent causing hemorrhagic cystitis
Antidote: MESNA
Cisplatin
for Advanced colon CA
Antidote: Amifostine
Procarbazine
causes Disulfiram reaction
Busulfan
causes Pulmonary fibrosis
Bone marrow SPARING
Carmustine
for Brain tumor
highly lipophilic –> CNS toxicity
Methotrexate
Inhibits dihydropteroate synthase
Antidote: Leucovirin
5-FU
Inhibit thymidylate synthase
Thymineless death
Cytarabine
Inhibit ribonucleotide reductase
for CML in blast Crisis
S phase
Vincristine
Prevent microtubule assembly
M phase
Vinblasline
Prevent microtubule assembly
M phase
6-Mercaptopurine
Inhibit de novo synthesis purine
PacIitaxel
Prevents microtubule DISASSEMBLY
for Advanced Breast & Ovarian CA
Doxorubicin
inhibit topoisomerase II
causes dilated cardiomyopathy
Antidote: Dexrazoxane
Bleomycin
for testicular CA
causes Pulmonary fibrosis
G2 phase
Imatinib
Inhibits bcr-abl oncogene tyrosine kinase activity
Trastuzumab
HER-2/neu rreceptor
for Metastatic Breast CA
Bevacizumab
inhibits VEGF
for DM retinopathy
Etoposide
Inhibit Topoisomerase II
Interferon Alpha
Hepatitis B & C
Topotecan
Inhibits Topoisomerase I
All trans Retinoic Acid
Differentiation therapy for Acute Promyelocytic Leukemia
Tamoxifen
Estrogen antagonist at Breast & CNS
ER/PR (+) Breast CA
Agonist at Uterus causing Endometrial Hyperplasia & CA
Flutamide
Androgen Competitive antagonist
Prostate CA
Rituximab
complement mediated lysis
