Chemotherapy drugs-TRADITIONAL anticancer tx Flashcards Preview

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Flashcards in Chemotherapy drugs-TRADITIONAL anticancer tx Deck (42):
1

Name the common traditional anticancer drug class

Alkylating agents
Antimetabolites
Anticancer antibiotics
Platinum Coordination complexes
Plant Derived product

2

Name the alkylating agent subclass

Nitrogen Mustard

3

Name a drug in the N-Mustard family

Cyclophosphamide

4

What is the MOA of cyclophosphamide

Forms a positively charged complex with CA cells DNA causing damage

5

Cyclophosphamide is used to treat

Lymphoma

6

What is the main AE of cyclophosphamide

Myelosuppresion

7

Name the antimetabolite subclass (folate antagonists)

Large folate

*analog of folic acid

8

Name a drug in the Large folate subclass

Methotrexate (MTX)

9

What is the MOA of MTX

Inhibits folic acid by binding to dihydrofolate reductase and thymid synthase

10

What is MTX use to tx

ALL

11

What is the main AE of MTX

Myelosuppression

12

Name the antimetabolite subclass (purine analogues)

Thiolyated purine

13

Name the drug in the thiolyated purine subclass (anti-purine)

thioguanine

14

What is the MOA of thioguanine

Inhibits purine synthesis

15

What is thioguanine use to tx

leukemia

16

What is the main AE associated with thioguanine

Myelosuppression

17

Name the antimetabolite subclass (pyrimidine analogues)

Halogenated pyrimidine

18

Name the halogenated pyrimidine (anti-pyrimidine)

5 Fluorouracil (5-FU)

19

What is the MOA of 5-FU

Inhibits thymid synthetase

20

What is 5-FU used to tx

colon CA

21

What is the main MOA of 5-FU

Myelosuppression

22

How does the anticancer ANTIBIOTICs work

By inhibiting nucleic acid synthesis by directly binding to the nucleic acid template or the polmerizing enzyme

23

Name two drug subclasses used as a antiCA antibiotic

Anthracyclines

Bleomycins

24

Name an anthracycline

Doxorubicin

25

What is the MOA of Doxorubicin

INTERCALATING agent that inserts b/t DNA base pairs in the S-phase of cell division

26

What is Doxorubicin used to tx

Solid tumors

27

What are the main AE associated with Doxorubicin

** Cardiac toxicity
* Myelosuppression

28

Name a bleomycin

Bleomycin

29

What is the MOA of bleomycin

Cuts DNA strand of CA cells

30

Bleomycin is used to tx

testicular CA

31

What is the main AE associated with bleomycin

Lung toxicity

32

How do Platinum Coordination Complexes work

By forming strong metal complexes with guanine on DNA

*binds N7,06 location

33

Name a Platinum coordination complex

Cisplatin

34

Name two subclasses derived from plant products

Vinca alkaloids

Taxanes

35

Name a Vinca alkaloid

Vincristine

36

What is the MOA of Vincristine

Binds to microtubule tubulin and blocks microtubule formation

37

What is Vincristine used to tx

ALL & Lymphoma

38

What is the main AE for vincristine

NeuroToxicity

39

Name a Taxane

Paclitaxel

40

What is the Paclitaxel MOA

Prevents microtubule disassembly

41

What is paclitaxel used to tx

Ovary and Breast CA

42

What is the main AE of paclitaxel

Myelosuppression