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Flashcards in Phosphodiesterase inhibitors Deck (20):
1

What role does phosphodiesterase play in cell signalling

PDE degrades cAMP/cGMP which causes a decrease in cell signalling

2

By inhibiting PDE, PDE inhibitors effect cell signaling how

by increasing the levels of the second messengers cAMP/cGMP

3

Name the classification of PDE inhibitors

Non-selective PDE inhibitors
PDE 1 Inhibitors
PDE 3 Inhibitors
PDE5 Inhibitors

4

Name a major family of non-selective PDE inhibitors

methylxanthines

5

Methylxanthines work by what two mechanisms

inhibits PDE

adenosine antagonist (A1/A2) receptors

*not alpha

6

Name four methylxanthines (nonselective PDEI)

Caffeine

Pentoxifylline

Papaverine

Theophylline

7

What are the two clinical uses of caffeine

treats PDPH
treats apnea of prematurity

8

What is pentoxifylline used to tx

PVD

*alters the rheology (flow) of RBCs

9

What is papaverine used for

spasmolytic producing vasodilation, GI sphincter, bronchiolar smooth muscle relaxation

relieves peripheral, myocardial and cerebral ischemia

*used in OR to prevent arterial vasospasm

10

What are the two actions of theophylline

smooth muscle relaxation>>bronchodilation

adenosine antagonist>>>cardiac stimulation

11

Name a PDE 1 inhibitor

Vinopectine

12

What is the MOA of vinopectine

inhibits calmodulin-stimulated PD

*leads to an increase in cGMP>>vasodilation of cerebral smooth muscles

*increases CPP>>increase memory and neuroprotection

13

Name five PDE 3 inhibitors

M.E.A.L.C
milrinone
enoximone
amrinone
levosimendan
cilostazol

14

What is Amrinones and Milrinone's action on the heart and vascular smooth muscle

Positive inotropic

Vasodilation>>decreased SVR, PVR, PAOP, MAP

15

Amrinone and Milrinone are indicated for

CHF

16

What is the MOA of PDE 5 inhibitorsf

specifically inhibits enzymes that degrade cGMP >>>vasodilatioin

17

Name four PDE 5 inhibitors

Dipyramidole

"nafil" Sildenafil, Vardenafil, Tadalafil

18

Dipyramidole exerts effects on what two elements

coronary vasculature>>vasodilation

platelets >>>antiplatelet activity

19

What are the two indications for dipyramidole

prevention of TIAs

inhibition of platelet aggregation for CABG and valve repair

20

What is the indication for sildenafil

erectile dysfunction

* enhances effect of NO in corpus cavernosum>>vasodilation>>>increased blood flow