Miscellaneous Drugs & Drug Interactions Flashcards Preview

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Flashcards in Miscellaneous Drugs & Drug Interactions Deck (44)
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1
Q

Name three commonly used dyes and contrast media

A

Methylene blue
Indigo carmine
Fluoroscein

2
Q

Methylene Blue is used for

A

evaluation of urine clearance time
to identify where ureters enter the bladder
treat methemoglobinemia

3
Q

Large doses of M. blue may cause

A

Nausea, abdominal pain, h/a, METHEMOGLOBINEMIA

4
Q

*IV bolus of M.Blue is associated with

A

TRANSIENT HYPOTENSION and False Sp02 reduction (dye changes blood color)

5
Q

Never give M.Blue

A

SQ, Intrathecally

6
Q

Indigo Carmine is used to

A

evaluate urine clearance time

to identify where ureters enter bladder

7
Q

I. Carmine is associated with

A

slight hypertension

8
Q

I. Carmine is prepared in a

A

0.8% solution in 5 mL ampules

9
Q

M. Blue is prepared in a

A

1% solution in 10 mL ampules

10
Q

Fluoroscein is used for

A

diagnostic angiography, or angioscopy of the fundus and iris vasculature

11
Q

Fluoroscein should not be

A

injected intrathecally

12
Q

Fluoroscein transiently causes skin and urine to turne

A

yellowish

13
Q

True or False, Fluroscein can cause allergic rxn

A

True

*caution in asthmatics

14
Q

The incidence of adverse drug interaction increases as the —— of concurrently administered drugs increases

A

Number

15
Q

Thiopental (pH 10.5) precipitates when mixed with

A

Opioids (pH 3-4)

16
Q

Heparin (acidic) is neutralized by

A

Protamine (basic)

17
Q

Local anesthetics mixed with —— prolongs the DOA of the LA

A

epinephrine

18
Q

Barbiturates are displaced from their protein binding site by ——- leading to an increase in the barbiturate effect

A

Contrast media

19
Q

Hepatic Cytochrome P-450 system is INDUCED by

A

Barbiturates/ Phenytoin

20
Q

** Pseudocholinesterase is inhibited by ——-, and thereby prolongs the DOA of ——-

A

Echothiphate (eye drop), Succinylcholine

21
Q

Phenobarital’s excretion is enhanced if the urine is alkalinized by

A

Sodium bicarbonate

22
Q

Alveolar elimination of volatile anesthetic agents are prolonged with what ventilatory depressant drug

A

Opioids

23
Q

Naloxone inhibits the acitivity of

A

Opioids

24
Q

*Magnesium increases the DOA of

A

Non-depolorizing muscle relaxants

25
Q

Chlorpromazine (thorazine) combined with —–, produces profound hypotension

A

halogenated agents

26
Q

Albuterol combined with ——– increase risk of dysrthythmias and hypertension

A

halogenated agents

27
Q

ANTIcholenesterases have what effect on the heart rate

A

SEVERE BRADYCARDIA

28
Q

Lidocaine can induce —– and decrease —–, and——.

A

induce and maintain anesthesia
decrease stress response during intubation
decrease MAC, if plasma levels maintained via infusion

29
Q

Isoflurane sensitize myocardium to

A

catecholamines

*epinephrine must be limited to 3.5 mcg/kg/10-minute period when given with Isoflurane

30
Q

MAO Inhibitors block metabolism of

A

Catecholamines

Nardil, Parnate, Marplan

31
Q

MOAIs should be stopped how long before surgery

A

2 weeks

32
Q

MAOIs have a synergestic effects with

A

halogenated agents, opioids, barbiturates

33
Q

What opioid is STRICTLY CONTRAINDICATED with MAOIs

A

Meperidine»>CNS excitation, hyperpyrexia, DEATH

34
Q

Tricylclc Antidepressants block reuptake of

A

Norephinephrine»»Profound Tachy, Hypertension

Elavil
Pamelor
Tofanil
Sinequan

35
Q

TCA should be continued until

A

the day of surgery

36
Q

** Pancuronium and cause ——when given with TCA

A

DYSRHYTHMIAS

37
Q

Cimetidine inhibits

A

P-450 system

38
Q

Cimetidine —-hepatic blood flow

A

decreases and thereby decreases the rate of biotransformation

39
Q

Acute alcohol intoxication ——-MAC

A

decreases

40
Q

Chronic alcohol abuse——MAC

A

increases

41
Q

Cocaine ——-reuptake of ——

A

Inhibits, reuptake of norepinephrine

42
Q

Key treatment goal of patient on cocaine

A

Avoid SNS stimulation due to exaggerated responses that can be life threatening.

43
Q

What NMBA should be avoid in cocaine users

A

Pancuronium

44
Q

All halogenated agents produce what effect of the heart

A

Myocardial depression