Chloraphenicol, Macrolides and Clindamycin Flashcards Preview

POD Exam II > Chloraphenicol, Macrolides and Clindamycin > Flashcards

Flashcards in Chloraphenicol, Macrolides and Clindamycin Deck (13):
1

Macrolides (3):

- Erythromycin
- Clarithromycin
- Azithromycin

2

Macrolide MOA:

Reversibly binds to the 50S ribosomal subunit of bacteria.
- Bacteriostatic.

3

Erythromycin ADRs:

- GI: cramps N/V/D
> Stimulates motilin.
- Thrombophlebitis
- Cholestatic hepatits
- Ototoxicity (IV large dose)
- QT prolongation (IV large dose)

4

Clarithromycin/azithromycin ADRs:

- GI
- HA
- Dizziness
- Allergic reactions

5

Macrolide spectrum of activity:

- Gram positive
- Atypicals
- H. flu, M. Cat (C/A only)
- H. pylori (C only)

6

Macrolide indications:

- PCN allergic pts.
- CAP (C/A)
- Mycoplasma pneumoniae
- Legionnaire's disease
- Chlamydia trachomatis non-gonococcal (not estolate form)

7

Clindamycin MOA:

- Binding of 50S ribosome leading to inhibition of protein synthesis.

8

Clindamycin spectrum of activity:

- Staph
- Strep
- Anaerobes
- Toxoplasmosis

9

Clindamycin ADRs:

- Allergic reactions
- Diarrhea
- C. difficile
- Hepatotoxicity

10

Chloramphenicol MOA:

Reversibly binds to the larger 50S subunit of the 70S ribosome.

11

Chloramphenicol absorption:

Oral > IV

12

Chloramphenicol spectrum of activity:

- Gram positive
- Gram negative
- Aerobic
- Anaerobic
- Rickettsia
- Chlamydia

13

Chloramphenicol indications:

- Bacterial meningitis
- Rickettsial infections