Cholinergics: Irreversible Acetylcholinesterase Inhibitors Flashcards Preview

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Flashcards in Cholinergics: Irreversible Acetylcholinesterase Inhibitors Deck (13)
1

irreversibly phosphorylate seine in substrate binding domaine of AchE

Acetychoinesterase inhibitors

2

regeneration of the enzyme is very slow (several hours) and significant regeneration of
the active enzyme usually is not observed

Acetychoinesterase inhibitors

3

- return of activity depends on synthesis of new enzyme

Acetychoinesterase inhibitors

4

sarin is a

Nerve gases

5

widely employed insecticide; greater safety than parathion because it is
rapidly detoxified in higher organisms

malathion

6

rapidly detoxificed in higher organisms

malthion

7

malthion is an insecticide that is:

Acetychoinesterase inhibitors

8

toxicity by irreversible inhibitors (organophosphate toxicity)

- SLUDGE, hypotension, bradycardia, difficulty with visual accommodation
- also: medullary respiratory center depression, muscle paralysis due to depolarizing
neuromuscular junction blockade
- death due to respiratory failure
- symptom onset depends on method of exposure (i.e., inhalation, ingestion, topical)

9

Toxic side effect of organosphosphates: medullary respiratory center________, muscle paralysis due to depolarizing

depression

10

Toxic effect of organophosphates: death due to

respiratory failure

11

Treatment from organophosphate poisoning:

- remove source of poisoning
- maintain an open airway and provide artificial respiration if required
- alleviation of convulsions with diazepam
- treatment of shock

12

atropine is a

– (muscarinic receptor antagonist)

13

blocks the peripheral and central muscarinic effects caused by organophosphates

atropine