Chronic Inflammation Flashcards Preview

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Flashcards in Chronic Inflammation Deck (39):
1

List the 4 cells involved in chronic inflammation

- Lymphocytes
- Macrophages
- Plasma cells
- Fibroblasts

2

What are the two different ways chronic inflammation can develop?

- From acute inflammation
- As a primary lesion

3

What is the process of it arising from acute inflammation?

- Large damage
- Inability to remove debris
- Failure to resolve

4

What are examples of chronic inflammation arising as a primary lesion?

- Autoimmune diseases
- Digestive resistant material
- Exogenous substances
- Endogenous substance

5

What are examples of exogenous substances?

- Sutures
- Glass

6

What are examples of endogenous substances?

- Keratin
- Hair
- Necrotic tissue

7

What 2 other things, disregarding scarring, can chronic inflammation result in?

- Fibrosis
- Granuloma formation

8

State 5 things that promote healing and repair

- Cleanliness
- Apposition of edges (suture)
- Good nutrition
- Metabolic stability
- Normal inflammatory functions

9

State 6 things that inhibit proper repair and healing

- Dirty wound
- Gaping wound
- Haemophilia
- Poor nourishment
- Abnormal CHO metabolism, diabetes
- Inhibition of angiogenesis

10

What vitamin deficiencies can result in poor healing

Vitamin C
Vitamin A

11

What systemic effects does TB cause?

- Malaise
- Cachexia

12

What is autoimmune thyrodosis an example of?

Loss of function

13

What is a plasma cell?

Mature B cell in circulation

14

What do macrophages produce in response to viruses?

Interferon

15

What are fibroblasts?

- Metabolically active cells
- Assemble structural proteins

16

What is produced during granulomatous inflammation?

Granulomas in tissue/organs

17

What is idiopathic disease?

Disease which we don't know the aetiology of

18

How are granulomas formed?

- They surround giant cells which come about in response to an indigestible antigen/exogenous or endogenous substance

19

What are granulomas normally surrounded by?

- Lymphocytes

20

What immune cells do granulomas contain?

- Neutrophils
- Eosinophils

21

What type of hypersensitivity are granulomas?

Type 4

22

What do giant cells consist of

- Macrophages fused together

23

Structure of a giant cell?

- Large cytoplasm
- Multinucleate

24

What is langhans giant cell usually found in?

TB

25

What is the structure of langhans type?

- Nuclei on outside
- Large eosinophilic cytoplasm

26

Which giant cell is associated with pyogenic granulation tissue?

Foreign body type

27

What type of giant cell comes about in response to a ruptured silicone implant?

- Silicone associated giant cell

28

Name some infectious granulomatous diseases

- TB
- Leprosy

29

Caseous Necrosis

- Cheesey necrosis

30

What cells surround the dead tissue in caseous necrosis

Macrophages, giant cells, neutrophils

31

Examples of non infective granulomas

- Crohns
- Sarcoidosis

32

What is sarcoidosis?

Granulomas appearing in organs all over the body

33

What is surgical wound healing an example of

Primary intention

34

What is healing larger defects left to?

Secondary intention

35

What is secondary intention?

- Forms large granulation tissue
- Large scar
- Scar tissue contracts

36

Sequence of events in fracture healing

- Trauma
- Bits of dead bone
- Acute inf.
- Granulation tissue contains osteoblasts as well as fibroblasts

37

What is callous formation a result from?

Osteoblasts laying down new bone

38

What stimulates proliferation of vessels

- Vascular endothelial growth factor

39

What cells release vascular endothelial growth factor?

Hypoxic cells