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Flashcards in Chronic Inflammation Deck (39)
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1

List the 4 cells involved in chronic inflammation

- Lymphocytes
- Macrophages
- Plasma cells
- Fibroblasts

2

What are the two different ways chronic inflammation can develop?

- From acute inflammation
- As a primary lesion

3

What is the process of it arising from acute inflammation?

- Large damage
- Inability to remove debris
- Failure to resolve

4

What are examples of chronic inflammation arising as a primary lesion?

- Autoimmune diseases
- Digestive resistant material
- Exogenous substances
- Endogenous substance

5

What are examples of exogenous substances?

- Sutures
- Glass

6

What are examples of endogenous substances?

- Keratin
- Hair
- Necrotic tissue

7

What 2 other things, disregarding scarring, can chronic inflammation result in?

- Fibrosis
- Granuloma formation

8

State 5 things that promote healing and repair

- Cleanliness
- Apposition of edges (suture)
- Good nutrition
- Metabolic stability
- Normal inflammatory functions

9

State 6 things that inhibit proper repair and healing

- Dirty wound
- Gaping wound
- Haemophilia
- Poor nourishment
- Abnormal CHO metabolism, diabetes
- Inhibition of angiogenesis

10

What vitamin deficiencies can result in poor healing

Vitamin C
Vitamin A

11

What systemic effects does TB cause?

- Malaise
- Cachexia

12

What is autoimmune thyrodosis an example of?

Loss of function

13

What is a plasma cell?

Mature B cell in circulation

14

What do macrophages produce in response to viruses?

Interferon

15

What are fibroblasts?

- Metabolically active cells
- Assemble structural proteins

16

What is produced during granulomatous inflammation?

Granulomas in tissue/organs

17

What is idiopathic disease?

Disease which we don't know the aetiology of

18

How are granulomas formed?

- They surround giant cells which come about in response to an indigestible antigen/exogenous or endogenous substance

19

What are granulomas normally surrounded by?

- Lymphocytes

20

What immune cells do granulomas contain?

- Neutrophils
- Eosinophils

21

What type of hypersensitivity are granulomas?

Type 4

22

What do giant cells consist of

- Macrophages fused together

23

Structure of a giant cell?

- Large cytoplasm
- Multinucleate

24

What is langhans giant cell usually found in?

TB

25

What is the structure of langhans type?

- Nuclei on outside
- Large eosinophilic cytoplasm

26

Which giant cell is associated with pyogenic granulation tissue?

Foreign body type

27

What type of giant cell comes about in response to a ruptured silicone implant?

- Silicone associated giant cell

28

Name some infectious granulomatous diseases

- TB
- Leprosy

29

Caseous Necrosis

- Cheesey necrosis

30

What cells surround the dead tissue in caseous necrosis

Macrophages, giant cells, neutrophils