Classic Lab 2 Flashcards Preview

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Flashcards in Classic Lab 2 Deck (59):
1

Heterophile antibodies

Infectious mononucleosis (EBV)

2

Hexagonal, double-pointed, needle-like crystals in bronchial secreations

Bronchial asthma (Charcot-Leyden crystals: eosinophilic granules)

3

High level of D-dimers

DVT, PE, DIC

4

Hilary lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)

Ghon complex (Primary TB Mycobacterium bacilli)

5

"honecomb lung" on xray or CT

Interstitial pulmonary fibrosis

6

Hypercoaguability (leading to migrating DVTs and vasculitis)

Trousseau syndrome (adenocarcinoma of pancreas or lung)

7

Hypersegmended neutrophils

Megaloblastic anemia (B12 deficiency: neurologic symptoms; folate deficiency: no neurolgic symptoms)

8

Hypertension, hypokalemia, metabolic alkalosis

Conn syndrome

9

Hypochromic, microcytic anemia

Iron deficiency anemia, lead poisoning, thalassemia ( fetal hemoglobin sometimes present)

10

Increased AFP in amniotic fluid/maternal serum

Datting error, anecephaly, spina bifida (neural tube defects)

11

Increase uric acid levels

Gout, Lesch-Nyhan syndrome, tumor lysis syndrome, loop and thiazide diuretics

12

Intranuclear eosinophilic droplet-like bodies

Cowdry type A bodies (HSV or CMV)

13

Iron-containing nodules in alveolar septum

Ferruginous bodies (asbestosis: increase chance of mesothelioma)

14

Keratin pearls on skin biopsy

Squamous cell carcinoma

15

Large lysosomal phagocytes, immunodeficient

Chediak-Higashi disease (congenital failure of phagolysosome formation)

16

"lead pipe" appearance of colon on barium enema xray

Ulcerative colitis (loss of haustra)

17

Linear appearance of IgG deposition on glomerular basement membrane

Goodpasture syndrome

18

Low serum ceroplasmin

Wilson Disease (hepatolenticular degeneration)

19

"Lumpy bumpy" apperance of glomeruli on immunoflourescence

Poststreptococcal glomerulonephritis (immune complex deposition of IgG and C3b)

20

Lytic (hole punched) bone lesions on xray

Multiple myeloma

21

Mammary gland "blue domed" cyst

Fibrocytic change of breast

22

Monoclonal antibody spike

Multiple myeloma (IgG or A)
Monoclononal gammopathy of undetermined significance (MGUS consequence of aging)
Waldenstrom (M protein = IgM) macroglobinemia
Primary amyloidosis

23

Mucin filled cell with peripheral nucleus

"Signet ring" = gastric carcinoma

24

Narrowing of bowel lumen on barium x-ray

"String sign" (Crohn disease)

25

Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis

Granulomatosis with polyangiitis (Wegner; PR3-ANCA/c-ANCA) and Good pastuure syndrome (anti-basement mmb antibodies)

26

Needle-shaped, negatively birefringent crystals

Gout (monosodium urate crystals)

27

Nodular hylaine deposits in glomeruli

Kimmelsteil-Wilson nodules (diabetic neuropathy)

28

Novobiocin response

Sensitive: Staphlococcus epidermidis;
resistant: Staphylococcus saphrophyticus

29

Nutmeg liver

Chronic passive congestion of liver dt Right heart failure

30

Onion skin peristeal reaction

Ewing sarcoma (malignant round cell tumor)

31

Optochin response

Sensitive: Streptococcus pneumoniae
Resistant: virdians streptococci

32

Periosteum raised from bone, creating triangular area

Codman triangle, on x-ray (osteosarcoma, Ewing sarcoma, pyogenic osteomylitis)

33

Podocyte fusion or "effacement" on EM

Minimal Change Disease (child with nephrotic syndrome)

34

Polished 'ivory like' appearance of bone at cartilage erosion

Eburnation (osteoarthritis resulting in bony sclerosis)

35

Protein aggregates in neurons from hyperphosphorylation of tau protein

Neurofibrillary tangles (Alzheimers) and Pick bodies (Pick disease)

36

Psammoma bodies

Meningiomas, Papillary Thyroid Cancer (PTC), mesothelioma, Papillary Serous carcinoma of the endometrium and ovary

37

Pseudopalisading tumor cells on brain biopsy

Glioblastoma multiforme

38

RBC casts in urine

Acute glomerulonephritis

39

Rectangular, crystal like cytoplasmic inclusions in Leydig cells

Reinke crystals ( Leydig cell tumor)

40

Renal epithelial casts in urine

Acute toxic/viral renal injury

41

Rhomboid crystals, + birefringent

Pseudogout (calcium pyrophospahte dihydrate cyrstals)

42

Rib notching

Coarctation of aorta

43

Ring-enhancing brain lesion in AIDS

Toxoplasma gondii, CNS lymphoma

44

Sheets of medium sized lymphoid cells with scattered pale tingible body-laden macrophage (starry sky histology)

Burkitt lymphoma (8:14) c-myc activation, associated with EBV; "black sky" made up of maligant cells

45

Silver stained spherical aggregation of tau proteins in neurons

Pick bodies (Pick disease: progressive dementia, change in personality)

46

"Soap bubble" in femur on tibia or xray

Giant cell tumor of bone (generally benign)

47

"Spikes" on basement membrane, "dome-like" subepithelial deposits

Membranous glomerulonephritis (may progress to nephrotic syndrome)

48

Stacks of RBCs

Rouleaux formation (high ESR, multiple myeloma)

49

Stippled vaginal epithelial cells

"Clue cells" Gardnella vaginalis

50

Tennis racket shaped cytoplasmic organelles (EM) in Langerhans cells

Birbeck granules (Langherhans cell histiocytosis or histiocytosis X: eosinophilic granuloma)

51

Thrombi made of white/red layers

Lines of Zahn (arterial thrombus/layers of platelets/RBCs)

52

"Thumb sign" on lateral xray

Epiglottitis (Haemophilus influenzae)

53

Tram track appearance of capillary loops of glomerular basement membranes on light microscopy

Membranoproliferative glomerulonephritis

54

Triglyceride accumulation in liver cell vacuoles

Fatty liver disease (alcoholic or metabolic syndrome)

55

"Waxy" casts with very low urine flow

Chronic end-stage renal disease

56

WBC casts in urine

Acute pyelonephritis

57

WBCs that look 'smudged'

CLL (almost always B cell)

58

"wire loop" glomerular capillary appearance on light imcroscopy

Lupus nephropathy

59

Yellowish CSF

Xanthochromia (d/t subarachnoid hemorrhage)