Classic Lab Findings Flashcards Preview

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Flashcards in Classic Lab Findings Deck (45):
1

Anticentromere antibodies

Sclerodomera/CREST

2

Antidesmoglein (epithelial) antibodies

Pemphigus vulgaris (blistering)

3

Anti-Glomerular basement membrane antibodies

Goodpasture Syndrome (glmerulonephritis adn hemoptysis)

4

Antihistone antibodies

Drug-induced SLE (hydralizine, INH, phenytoin, procainamide)

5

Antimitochondrial antibodies (AMA)

Primary biliary cirrhosis (female, cholestasis, portal HTN)

6

Anti-IgG antibodies

RA (sytemic inflammation, joint pannus, bouteonneir deformity)

7

Antineutrophil cytoplasmic antibodies (ANCA)

Microscopic polyangitis adn Churg-Strauss syndrome (MPO-ANCA/p-ANCA); granulomatosis w/ polyangitis (Wegener; PR3-ANCA/c-ANCA)

8

Antinuclear antibodies; ANA: anti-Smith or anti-dsDNA

SLE; Type III hypersensitivity

9

Antiplatelet antibodies

Idiopathic thrombocytopenic purpura

10

Anti-topioisomerase antibodies

Diffuse systemic sclerodema

11

Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies

Celiac's disease; diarrhea, distension and weight loss

12

"Apple Core" lesion on abdominal xray

Colorectal cancer

13

Azurophilic peroxidase + granular inclusions in granulocytes and myeloblasts

Auer rods in AML; especially the promyelocytic M3 type

14

Bacitracin response

Sensitive; Streptococcus Pyogenes group A
resistant; Streptococcus agalactiae group B

15

Bamboo spine on x ray

Ankylosing spondylitis (chronic inflammatory arthritis: HLA-B27)

16

Basophilic nuclear remnants in RBCs

Howell-Jolly bodies~ splenectomy or nonfunctional spleen

17

Basophilc stippling of RBCs

lead poisoning or sideroblastic anemia

18

Bloody tap on LP

subarchonoid hemorrhage

19

"Boot-shaped" heart

Tetrology of Fallot, RVH

20

Branching gram + rods with sulfur granules

Actinomyces israelli

21

Bronchogenic apical lung tumor on imaging

Pancoast tumor; can compress sympathetic ganglion causing Horner syndrome)

22

"Brown" tumor of bone

Hyperparathydoidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage)

23

Cadiomegaly with apical atrophy

Chagas disease (Trypanosoma cruzi)

24

Cellular crescents in Bowman capsule

Rapidly progressive cresentic glomerulonephritis

25

"Chocolate cyst" of ovary

Endometriosis (often both ovaries)

26

Circular grouping of dark tumor cells surrounding pale neurfibrils

Homer-Wright rossettes (neuroblastoma, medulloblastoma, retinoblastoma)

27

Colonies of mucoid Pseudomonas in lungs

Cystic fibrosis--> autosomal recessive mutations in CFTR gene--> fat-soluble vitamin deficiency and mucous plugs)

28

Decrease AFP in amniotic fluid/maternal serum

Down syndrome or other chromosomal abnormalities

29

Degeneration of dorsal column nerves

Tabes dorsalis (tertiary syphillis) subacute combined degernation (dorsal columns and lateral corticospinal tracts affected)

30

Depigmentation of neurons in substantia nigra

Parkinsons disease; basal ganglia disorder)

31

Desquamated epithelium casts in sputum

Curshmann spirals (bronchial asthma; resluts in whorled mucus plugs)

32

Disarrayed granulosa cells in eosinophilic fluid

Call0Exner bodies (granulosa-theca cell tumor of ovary)

33

Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia

Koilocytes (HPV: predisposes to cervical cancer)

34

Enlarged cells with intranuclear inclusion bodies

Owl eye of CMV

35

Enlarged thyroid cells with ground glass nuclei

'orphan annie' eyes nuclei in papillary carcinoma of thyrpoid

36

eosinophilic cytoplasmic inclusion in liver cell

Mallory Body (alcoholic liver disease)

37

Eosinophilic cytoplasmic inclusion in nerve cell

Lewy body of Parkinson disease

38

Eosinophilic globule in liver

Councilman body--viral or toxic hepatitis, often yellow fever)

39

Eosinophilic inclusion bodies in cytoplasm of hippocampal and cerebral nerve cells

Negri bodies of rabies

40

Extracellular amyloid deposition in gray matter

Senile plaques (Alzheimer disease)

41

Giant B cells with bilobed nuclei with prominent inclusions (owl eye)

Reed-Sternberg cells of Hodkin lymphoma

42

Glomerulus like structure surrounding vessels in germ cells

Schiller-Duval bodies = yolk sac tumor

43

"hair on end" crew cut appearance on xray

B-thalessemia, sickel cell anemia (marrow expansion)

44

hCG elevation

Choriocarcinoma, hydatiform mole

45

Heart nodules (granulomatous)

Aschoff bodies from rheumatic fever