Flashcards in Classic Lab Findings Deck (45):
1
Anticentromere antibodies
Sclerodomera/CREST
2
Antidesmoglein (epithelial) antibodies
Pemphigus vulgaris (blistering)
3
Anti-Glomerular basement membrane antibodies
Goodpasture Syndrome (glmerulonephritis adn hemoptysis)
4
Antihistone antibodies
Drug-induced SLE (hydralizine, INH, phenytoin, procainamide)
5
Antimitochondrial antibodies (AMA)
Primary biliary cirrhosis (female, cholestasis, portal HTN)
6
Anti-IgG antibodies
RA (sytemic inflammation, joint pannus, bouteonneir deformity)
7
Antineutrophil cytoplasmic antibodies (ANCA)
Microscopic polyangitis adn Churg-Strauss syndrome (MPO-ANCA/p-ANCA); granulomatosis w/ polyangitis (Wegener; PR3-ANCA/c-ANCA)
8
Antinuclear antibodies; ANA: anti-Smith or anti-dsDNA
SLE; Type III hypersensitivity
9
Antiplatelet antibodies
Idiopathic thrombocytopenic purpura
10
Anti-topioisomerase antibodies
Diffuse systemic sclerodema
11
Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies
Celiac's disease; diarrhea, distension and weight loss
12
"Apple Core" lesion on abdominal xray
Colorectal cancer
13
Azurophilic peroxidase + granular inclusions in granulocytes and myeloblasts
Auer rods in AML; especially the promyelocytic M3 type
14
Bacitracin response
Sensitive; Streptococcus Pyogenes group A
resistant; Streptococcus agalactiae group B
15
Bamboo spine on x ray
Ankylosing spondylitis (chronic inflammatory arthritis: HLA-B27)
16
Basophilic nuclear remnants in RBCs
Howell-Jolly bodies~ splenectomy or nonfunctional spleen
17
Basophilc stippling of RBCs
lead poisoning or sideroblastic anemia
18
Bloody tap on LP
subarchonoid hemorrhage
19
"Boot-shaped" heart
Tetrology of Fallot, RVH
20
Branching gram + rods with sulfur granules
Actinomyces israelli
21
Bronchogenic apical lung tumor on imaging
Pancoast tumor; can compress sympathetic ganglion causing Horner syndrome)
22
"Brown" tumor of bone
Hyperparathydoidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage)
23
Cadiomegaly with apical atrophy
Chagas disease (Trypanosoma cruzi)
24
Cellular crescents in Bowman capsule
Rapidly progressive cresentic glomerulonephritis
25
"Chocolate cyst" of ovary
Endometriosis (often both ovaries)
26
Circular grouping of dark tumor cells surrounding pale neurfibrils
Homer-Wright rossettes (neuroblastoma, medulloblastoma, retinoblastoma)
27
Colonies of mucoid Pseudomonas in lungs
Cystic fibrosis--> autosomal recessive mutations in CFTR gene--> fat-soluble vitamin deficiency and mucous plugs)
28
Decrease AFP in amniotic fluid/maternal serum
Down syndrome or other chromosomal abnormalities
29
Degeneration of dorsal column nerves
Tabes dorsalis (tertiary syphillis) subacute combined degernation (dorsal columns and lateral corticospinal tracts affected)
30
Depigmentation of neurons in substantia nigra
Parkinsons disease; basal ganglia disorder)
31
Desquamated epithelium casts in sputum
Curshmann spirals (bronchial asthma; resluts in whorled mucus plugs)
32
Disarrayed granulosa cells in eosinophilic fluid
Call0Exner bodies (granulosa-theca cell tumor of ovary)
33
Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia
Koilocytes (HPV: predisposes to cervical cancer)
34
Enlarged cells with intranuclear inclusion bodies
Owl eye of CMV
35
Enlarged thyroid cells with ground glass nuclei
'orphan annie' eyes nuclei in papillary carcinoma of thyrpoid
36
eosinophilic cytoplasmic inclusion in liver cell
Mallory Body (alcoholic liver disease)
37
Eosinophilic cytoplasmic inclusion in nerve cell
Lewy body of Parkinson disease
38
Eosinophilic globule in liver
Councilman body--viral or toxic hepatitis, often yellow fever)
39
Eosinophilic inclusion bodies in cytoplasm of hippocampal and cerebral nerve cells
Negri bodies of rabies
40
Extracellular amyloid deposition in gray matter
Senile plaques (Alzheimer disease)
41
Giant B cells with bilobed nuclei with prominent inclusions (owl eye)
Reed-Sternberg cells of Hodkin lymphoma
42
Glomerulus like structure surrounding vessels in germ cells
Schiller-Duval bodies = yolk sac tumor
43
"hair on end" crew cut appearance on xray
B-thalessemia, sickel cell anemia (marrow expansion)
44
hCG elevation
Choriocarcinoma, hydatiform mole
45