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Flashcards in MARKERS Deck (42):
1

BRC-ABL

Oncogene: CML, ALL, tyrosine kinase

2

bcl-2

Oncogene: Follicular and undifferentiated lymphomas; anti-apoptotic moleculre

3

BRAF

Oncogene, melanoma, Serone/threonin kinase

4

c-kit

Gastrointestinal stromal tumor, oncogene, Cytokine receptor

5

c-myc

Burkitt lymphoma, transcription factor

6

HER2/neu

breast, ovarian, gastric carcinoma with tyrosine kinase

7

L-myc

Lung tumor; transcription factor

8

N-myc

Neuroblastoma: transcription factor

9

ras

colon cancer, lung cancer, pancreatic
GTPase

10

ret

MEN 2A and 2B; Tryosine kinase

11

APC
BRCA1
BRACA2

APC = colorectal
BRCA1 = breast and ovarian
BRCA2- breast and ovarian

12

CPD4/SMAD4

Pancreatic cancer makes DPC or Deleated in Pancreatic Cancer

13

DCC

Colon cancer: Deleated in Colon Cancer

14

p16

Melanoma; cyclcin dependent kinase inhibitor 2A

15

PTEn

breast cancer, prostate cancer, endometrial

16

Rb

retinoblastoma and Osteosarcoma: inhibits EF2 to stop G1--> S

17

TSC1
TSC2

both Tuberous sclerosis
1 = hamartin protein
2=Tuberin protein

18

Elevated Alk Phos is indication for

Metastases to bone or liver, Paget disease of bone, seminoma (placental ALP).

19

α-fetoprotein

Hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, mixed germ cell tumor.
*Normally made by fetus. Transiently elevated in pregnancy; high levels associated with neural tube and abdominal wall defects, low levels associated with Down syndrome.

20

β-hCG

Hydatidiform moles and Choriocarcinomas (Gestational trophoblastic disease), testicular cancer, mixed germ cell tumor.
*produced by syncytiotrophoblasts of the placenta.

21

Elevated CA-15-3/CA-27-29

Breast cancer

22

Elevated CA-19-9

Pancreatic adenocarcinoma

23

Elevated CA-125

Ovarian cancer

24

Elevated CEA

Carcino Embryonic Antigen.
Very nonspecific but produced by ∼ 70% of colorectal and pancreatic cancers; also produced by gastric, breast, and medullary thyroid carcinomas.

25

EBV causes what cancer

Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, 1° CNS lymphoma (in immunocompromised patients)

26

Infection with HBV, HCV

HCC increases

27

Infection HHV-8

Kaposi's sarcoma

28

HPV infection

Cervical and penile/anal carcinoma (types 16, 18), head and neck cancer

29

H.pylori infection

Gatric adenocarcinoma and MALT oma

30

HTLV-1

associated with adult T-cell leukemia and lymphoma

31

Liver fluke: Clonorchis Sinensis

Cholangiocarcinoma

32

Schistosoma haematobium

Bladder Cancer

33

What neosplasms release 1,25 OH2, D3 resulting in Hypercalcemia

Hodgkin lymphoma, and some non

34

What neoplasms result in Paraneoplastic release of ACTH causing Cushing sydnrome

Small cell lung

35

What neoplasm causes paraneoplastic release of ADH leading to SIADH

Small cell lung and Intracranial neoplasms

36

What neoplasm release antiB to presynaptic Ca++ at the NMJ resulting in Lambert Eaton

Small Cell lung

37

What neoplasm releases EPO causing Polycythemia?

RCC, Thymoma, Hemangioblastoma, HCC, Leiomyoma, Pheocromocytoma

38

What malignancy releases PTHrP causing hypercalcemia?

Squamous cell lung, RCC or breast

39

What shit has Psammoma bodies?

PSaMMoma: Papillary carc of thyroid, Serious papillary cystadenocarcinom of ovary, Meningioma, Malignant mesothelioma

40

What tumors will Met to the BRAIN?

Lung> Breast > Genitourinary>Osteosarcoma; often multiple and well circumscribed

41

What tumors with MET to the LIVER

Colon >> Stomach> pancrease

42

What tumors with MET to the BONE

Prostate or Breast >lung>thyroid; more common then primary bone tumor