classic labs/findings 2 Flashcards

(61 cards)

1
Q

Heart nodules (granulomatous)

A

Aschoff bodies (rheumatic fever)

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2
Q

Heterophile antibodies

A

Infectious mononucleosis (EBV)

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3
Q

Hexagonal, double-pointed, needle-like crystals in bronchial secretions

A

Bronchial asthma (Charcot-Leyden crystals: eosinophilic granules)

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4
Q

High level of D-dimers

A

DVT, PE, DIC

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5
Q

Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)

A

Ghon complex (1° TB: Mycobacterium bacilli)

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6
Q

“Honeycomb lung” on x-ray or CT

A

Interstitial pulmonary fibrosis

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7
Q

Hypercoagulability (leading to migrating DVTs and vasculitis)

A

Trousseau syndrome (adenocarcinoma of pancreas or lung)

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8
Q

Hypersegmented neutrophils

A

Megaloblastic anemia (B12 deficiency: neurologic symptoms; folate deficiency: no neurologic symptoms)

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9
Q

Hypertension, hypokalemia, metabolic alkalosis

A

Conn syndrome

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10
Q

Hypochromic, microcytic anemia

A

Iron deficiency anemia, lead poisoning, thalassemia (fetal hemoglobin sometimes present)

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11
Q

Increased AFP in amniotic fluid/maternal serum

A

Dating error, anencephaly, spina bifida (neural tube defects)

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12
Q

Increased uric acid levels

A

Gout, Lesch-Nyhan syndrome, tumor lysis syndrome, loop and thiazide diuretics

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13
Q

Intranuclear eosinophilic droplet-like bodies

A

Cowdry type A bodies (HSV or CMV)

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14
Q

Iron-containing nodules in alveolar septum

A

Ferruginous bodies (asbestosis:

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15
Q

Keratin pearls on a skin biopsy

A

Squamous cell carcinoma

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16
Q

Large lysosomal vesicles in phagocytes, immunodeficiency

A

Chédiak-Higashi disease (congenital failure of phagolysosome formation)

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17
Q

“Lead pipe” appearance of colon on barium enema x-ray

A

Ulcerative colitis (loss of haustra)

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18
Q

Linear appearance of IgG deposition on glomerular basement membrane

A

Goodpasture syndrome

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19
Q

Low serum ceruloplasmin

A

Wilson disease (hepatolenticular degeneration)

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20
Q

“Lumpy bumpy” appearance of glomeruli on immunofluorescence

A

Poststreptococcal glomerulonephritis (immune complex deposition of IgG and C3b)

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21
Q

Lytic (“hole punched”) bone lesions on x-ray

A

Multiple myeloma

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22
Q

Mammary gland (“blue domed”) cyst

A

Fibrocystic change of the breast

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23
Q

Monoclonal antibody spike

A
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24
Q

Mucin-filled cell with peripheral nucleus

A

“Signet ring” (gastric carcinoma)

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25
Narrowing of bowel lumen on barium x-ray
“String sign” (Crohn disease)
26
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis
Granulomatosis with polyangiitis (Wegener; PR3-ANCA/ c-ANCA) and Goodpasture syndrome (anti–basement membrane antibodies)
27
Needle-shaped, negatively birefringent crystals
Gout (monosodium urate crystals)
28
Nodular hyaline deposits in glomeruli
Kimmelstiel-Wilson nodules (diabetic nephropathy)
29
Novobiocin response
Sensitive: Staphylococcus epidermidis; resistant: Staphylococcus saprophyticus
30
“Nutmeg” appearance of liver
Chronic passive congestion of liver due to right heart failure
31
“Onion skin” periosteal reaction
Ewing sarcoma (malignant round-cell tumor)
32
Optochin response
Sensitive: Streptococcus pneumoniae; resistant: viridans streptococci
33
Periosteum raised from bone, creating triangular area
Codman triangle on x-ray (osteosarcoma, Ewing sarcoma, pyogenic osteomyelitis)
34
Podocyte fusion or “effacement” on electron microscopy
Minimal change disease (child with nephrotic syndrome)
35
Polished, “ivory-like” appearance of bone at cartilage erosion
Eburnation (osteoarthritis resulting in bony sclerosis)
36
Protein aggregates in neurons from hyperphosphorylation of tau protein
Neurofibrillary tangles (Alzheimer disease) and Pick bodies (Pick disease)
37
Psammoma bodies
Meningiomas, papillary thyroid carcinoma, mesothelioma, papillary serous carcinoma of the endometrium and ovary
38
Pseudopalisading tumor cells on brain biopsy
Glioblastoma multiforme
39
RBC casts in urine
Acute glomerulonephritis
40
Rectangular, crystal-like, cytoplasmic inclusions in Leydig cells
Reinke crystals (Leydig cell tumor)
41
Renal epithelial casts in urine
Acute toxic/viral renal injury
42
Rhomboid crystals, positively birefringent
Pseudogout (calcium pyrophosphate dihydrate crystals)
43
Rib notching
Coarctation of the aorta
44
Ring-enhancing brain lesion in AIDS
Toxoplasma gondii, CNS lymphoma
45
Sheets of medium-sized lymphoid cells with scattered pale, tingible body–laden macrophages (“starry sky” histology)
Burkitt lymphoma (t[8:14] c-myc activation, associated with EBV; “black sky” made up of malignant cells)
46
Silver-staining spherical aggregation of tau proteins in neurons
Pick bodies (Pick disease: progressive dementia, changes in personality)
47
“Soap bubble” in femur or tibia on x-ray
Giant cell tumor of bone (generally benign)
48
“Spikes” on basement membrane, “dome-like” subepithelial deposits
Membranous glomerulonephritis (may progress to nephrotic syndrome)
49
Stacks of RBCs
Rouleaux formation (high ESR, multiple myeloma)
50
Stippled vaginal epithelial cells
“Clue cells” (Gardnerella vaginalis)
51
“Tennis racket”-shaped cytoplasmic organelles (EM) in Langerhans cells
Birbeck granules (Langerhans cell histiocytosis or histiocytosis X: eosinophilic granuloma)
52
Thrombi made of white/red layers
Lines of Zahn (arterial thrombus, layers of platelets/RBCs)
53
“Thumb sign” on lateral x-ray
Epiglottitis (Haemophilus influenzae)
54
Thyroid-like appearance of kidney
Chronic bacterial pyelonephritis
55
“Tram-track” appearance of capillary loops of glomerular basement membranes on light microscopy
Membranoproliferative glomerulonephritis
56
Triglyceride accumulation in liver cell vacuoles
Fatty liver disease (alcoholic or metabolic syndrome)
57
“Waxy” casts with very low urine flow
Chronic end-stage renal disease
58
WBC casts in urine
Acute pyelonephritis
59
WBCs that look “smudged”
CLL (almost always B cell)
60
“Wire loop” glomerular capillary appearance on light microscopy
Lupus nephropathy
61
Yellowish CSF
Xanthochromia (e.g., due to subarachnoid hemorrhage)