Classic Labs/Findings 3

Question 1

Giant B-cells with bilobed nuclei with prominent inclusions (owl’s eye”)?

Answer 1

Reed-Sternberg cells (Hodgkin’s lymphoma)

Question 2

Glomerulus-like structure surrounding vessel in germ cells?

Answer 2

Schiller-Duval bodies (yolk sac tumor)

Question 3

“Hair on end” (crewcut) appearance on x-ray?

Answer 3

B-thalassemia, sickle cell (marrow expansion)

Question 4

hCG elevated?

Answer 4

Choriocarcinoma, hydatidiform mole (occurs with and without embryo)

Question 5

Heart nodules (granulomatous)?

Answer 5

Aschoff bodies (rheumatic fever)

Question 6

Heterophile Abs?

Answer 6

Infectious mononucleosis (EBV)

Question 7

Hexagonal, double-pointed, needle-like crystals in bronchial secretions?

Answer 7

Bronchial asthma (Charcot-Leyden crystals: eosinophilic granules)

Question 8

High level of D-dimers?

Answer 8

DVT, pulmonary embolism, DIC

Question 9

Hilar LAD, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)?

Answer 9

Ghon complex (primary TB)

Question 10

“Honeycomb lung” on x-ray or CT?

Answer 10

Interstitial pulmonary fibrosis

Question 11

Hypercoagulability (leading to migrating DVTs and vasculitis)?

Answer 11

Trousseau’s syndrome (adenocarcinoma of pancreas or lung)

Question 12

Hypersegmented neutrophils?

Answer 12

Megaloblastic anemia (B12 deficiency: neuro sxs; folate deficiency: no neuro sxs)

Question 13

HTN, hypokalemia, metabolic alkalosis?

Answer 13

Conn’s syndrome

Question 14

Hypochromic, microcytic anemia?

Answer 14

Fe deficiency anemia, lead poisoning, thalassema (fetal Hb sometimes present)

Question 15

Increased a-fetoprotein in amniotic fluid/maternal serum?

Answer 15

Dating error, anencephaly, spina bifidia (neural tube defects)

Question 16

Increased uric acid levels?

Answer 16

Gout, Lesch-Nyhan, tumor lysis syndrome, loop and thiazide diuretics

Question 17

Intranuclear eosinophilic droplet-like bodies?

Answer 17

Cowdry type A bodies (HSV or CMV)

Question 18

Fe-containing nodules in alveolar septum?

Answer 18

Ferruginous bodies (asbestosis: high chance of mesothelioma)

Question 19

Keratin pearls on skin biopsy?

Answer 19

SCC

Question 20

Large lysosomal vesicles in phagocytes, immunodeficiency?

Answer 20

Chediak-Higashi dz (congenital failure of phagolysosome formation)