Classic Labs/Findings 1

Question 1

Anticentromere Abs?

Answer 1

Scleroderma (CREST)

Question 2

Antidesmoglein (epithelial) Abs?

Answer 2

Pemphigus vulgaris (blistering)

Question 3

Anti-glomerular BM Abs?

Answer 3

Goodpasture’s (glomerulonephritis + hemoptysis)

Question 4

Antihistone Ab?

Answer 4

Drug-induced SLE (hydralazine, isoniazid, phenytoin, procainamide)

Question 5

Anti-IgG Abs?

Answer 5

Rheumatoid arthritis (systemic inflammation, joint pannus, boutonniere deformity)

Question 6

Antimitochondrial Abs (AMAs)?

Answer 6

Primary biliary cirrhosis (female, cholestasis, portal HTN)

Question 7

Antineutrophil cytoplasmic Abs (ANCAs)?

Answer 7

Vasculitis (c-ANCA: granulomatosis with polyangiitis [Wegener’s]; p-ANCA: microscopic polyangiitis, Churg-Strauss)

Question 8

Antinuclear Abs (ANAs: anti-Smith and anti-dsDNA)?

Answer 8

SLE (type III HSR)

Question 9

Antiplatelet Abs?

Answer 9

Idiopathic thrombocytopenic purpura

Question 10

Anti-topoisomerase Abs?

Answer 10

Diffuse systemic scleroderma

Question 11

Anti-transglutaminase/anti-gliadin/anti-endomysial Abs?

Answer 11

Celiac dz (diarrhea, distention, weight loss)

Question 12

“Apple core” lesion on abdominal x-ray?

Answer 12

Colorectal cancer (usually left-sided)

Question 13

Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblasts?

Answer 13

Auer rods (acute myelogenous leukemia, esp the promyelocytic [M3] type)

Question 14

Bacitracin response?

Answer 14

Sensitive: Strep pyogenes (group A); resistant: Strep agalactiae (group B)

Question 15

“Bamboo spine” on x-ray?

Answer 15

Ankylosing spondylitis (chronic inflammatory arthritis; HLA-B27)

Question 16

Basophilic nuclear remnants in RBCs?

Answer 16

Howell-Jolly bodies (due to splenectomy or nonfunctional spleen)

Question 17

Basophilic stippling of RBCs?

Answer 17

Lead poisoning or sideroblastic anemia

Question 18

Bloody tap on LP?

Answer 18

Subarachnoid hemorrhage

Question 19

“Boot shaped” heart on x-ray?

Answer 19

Tetralogy of Fallot, RVH

Question 20

Branching gram-positive rods with sulfur granules?

Answer 20

Actinomyces israeli