Clinical 5 - Obstructive Pulmonary Diseases Flashcards Preview

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Flashcards in Clinical 5 - Obstructive Pulmonary Diseases Deck (15)
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1

What are the characteristics of emphysema?

Enlargement of air spaces
Destruction of alveolar walls
Weight loss

2

What chromosome is a1AT on?

Chromosome 14

3

What is the genetic inheritance of a1AT?

AR

4

What is the phenotype of a1AT?

PiZZ

5

What is a1AT?

Secretory glycoprotein
Inhibits proteolytic enzymes

6

How do you treat a1AT?

Replacement therapy

7

What are the treatment options for COPD?

Bronchodilators
Proper inhalation technique

8

What are the hallmarks of asthma?

Mucus gland hypertrophy
Mucus hypersecretion
Epithelial desquamation
Widening of basement membrane
Eosinophilic infiltration

9

What GI condition may exacerbate asthma?

GERD

10

What is the diagnostic features of allergic bronchopulmonary aspergillosis?

Develops in patients with asthma and/or CF
Increased IgE
Radiographic infiltrates
Peripheral blood eosinophilia

11

What is the treatment for allergic bronchopulmonary aspergillosis?

Corticosteroids

12

What is obstructive sleep apnea?

Periodic cessation of air-flow (>10 sec) during sleep due to obstruction of upper airway

13

What are the three characteristics of patients with sleep apnea?

Obese
Known to snore
Complain of daytime sleepiness

14

What is the treatment for sleep apnea?

Continuous positive airway pressure
Bilevel positive airway pressure
Tracheostomy in severe cases

15

What does the PFT show in diffuse lung disease?

Restrictive change with various degrees of gas exchange abnormalities and hypoxemia