Clinical Pathological Conference of the Ovary

Question 1

What genes are associated with ovarian cancer?

Answer 1

BRCA1/2

HNPCC/Lynch type II

Question 2

What are the symptoms of ovarian cancer?

Answer 2

Indigestion/early satiety
Altered bowel habit
Bloating/discomfort
Pelvic mass

Question 3

How is ovarian cancer diagnosed?

Answer 3

Surgical/pathological
USS abdo pelvix
CT scan
CA 125

Question 4

What is CA 125?

Answer 4

Glycoprotein antigen raised in ovarian cancer

Question 5

CA 125 is raised in what?

Answer 5

Ovarian/colon/breast cancer
PID
Liver disease
Recent surgery
Endometriosis

Question 6

What are the stages of ovarian cancer?

Answer 6

1 - Limited to ovaries with capsule intact
2 - Pelvic extension
3 - Peritoneal implants outside pelvis
4 - Distant metastasis

Question 7

How is ovarian cancer treated?

Answer 7

Surgery

Chemotherapy

Question 8

What is the use of laparotomy in ovarian cancer?

Answer 8

Obtain tissue diagnosis
Stage disease
Disease clearance
Debulk disease

Question 9

What chemotherapy is used in ovarian cancer?

Answer 9

Within 8wks of surgery

Platinum and taxane

Question 10

How is recurrent ovarian cancer managed?

Answer 10

Chemotherapy
Palliation
Platinum
Surgery
Tamoxifen, anti-estrogens

Question 11

What are borderline ovarian cysts?

Answer 11

Papillae on surface of ovary/lining cyst

Can seed within peritoneal cavity

Question 12

What is the lifetime risk of ovarian cancer with the BRCA gene?

Answer 12

15-45%