CML

Question 1

What is CML strongly associated with?

Answer 1

Philadelphia chromosome t(9;22)

Question 2

How does Philadelphia chromosome cause CML?

Answer 2

Proto-oncogene from chromosome 9 fused with BCR gene on chromosome 22 causing excess tyrosine kinase activity

Question 3

What is the classic presentation on blood oil. in CML?

Answer 3

Increase in granulocytes at different stages of maturation +/- thrombocytosis

Question 4

What are the common presenting features of CML?

Answer 4

Anaemia, weight loss, sweats
Splenomegaly

Question 5

What is the first line management of CML?

Answer 5

Imatinib - TKI

Question 6

What are management options in CML?

Answer 6

Imatinib - TKI
Hydroxycarbamide
Interferon alpha
Allogenic transplant