List the five primary rule-outs for CNS disease in nursery pigs:
- Streptococcal meningitis
- Glasser's disease (Haemophilus parasuis)
- Edema disease
Etiology of edema disease
Pathophysiology of Edema Disease
E. coli adheres to gut fimbria (F-18ab) and produces toxin (EDP or Shiga-like toxin) which damages vascular endothelium in various tissues. May or may not produce enterotoxin leading to secretory diarrhea.
Lesions of edema disease
Edema of stomach, colon, eyelids.
Edema disease has non-specific neurological signs due to edema and necrosis of the ______.
Salt-poisoning/Water deprivation causes ___-osmolarity of the CNS.
Rapid rehydration in salt-poisoning/water deprivation results in osmotic _____ of the brain.
If fibrin is noted upon necropsy in nursery pigs, think _____ or ____.
Glasser's (Haemophilus parasuis) or Strep
Upon necropsy of a neonatal pig, if you see edema of stomach and eyelids, think _____.
Diagnostic tests -
Culture the meninges to detect ___ or _____. Culture the intestines for _____.
Meninges - Strep or H. parasuis
Intestines - E. coli
Upon histopathology of the brain, purulent meningitis makes you suspicious of ____ or _____.
Strep or H. parasuis
Upon histopathology on the brain, eosinophilic perivascular cuffing makes you suscpicious of ____.
Salt poisoning/Water deprivation
Upon histpath on the brain, if you see non-suppurative meningoencephalomyelitis, think ________.
Vaccinations are present for these three CNS diseases:
- H. parasuis
- PRV (pseudorabies)
Antibiotics are only effective against CNS disease in nursery pigs if given _____.