Flashcards in CNS Drug List Deck (38):
what is the glutamate receptor and what is its mechanism?
NMDA and ^ Ca2+, Na2+, K+ conductance
what drugs decrease NMDA release?
morphone, heroin, and THC
what drugs decrease NMDA receptor activation
What are the two receptors associated with Acetylcholine?
M and N
what is the mechanism of Acetycholine?
G-protein linked: ^ IP3, ^ DAG, and decrease K+ conductance
Ion channels: ^ Na+, K+ conductance
what is a direct agonist for acetylcholine, and an antagonist?
what are two inhibitory neurotransmitters?
GABA and Dopamine
what are the two GABA receptros, and what is the mechanism of GABA?
a and b
ionchannel: ^ CL- conductance
what decreases the release of GABA?
THC, morphine and Heroin
what do these 3 drugs do?
Increase GABAa receptor activation
what is the receptor and mechanism of Dopamine?
Presynatic: G-protein -> decrease Ca+2 conductance
postsynaptic: G-protein -> ^ K+ conducntance and decrease cAMP
what drug increases dopamine synthesis?
what drug increases dopamine release?
what drug decreases dopamine reuptake?
what drug decreases dopamine metabolism?
phenelzine and selegiline
what is a D2 agonist?
what is a D2 antagonist?
what is the cause of AD? (alzheimers Disease)
loss of cholinergic projection neurons,
what is the cause of Parkinsons Dieaseas?
loss of nigro-striatal dopamine projection neurons
how is dopamine linked to psychosis and schizophrenia?
excess dopamine neurotransmission in limbic system
name the 3 receptors and linked mechanism to norepinephrine
alpha1-> g-protein: ^IP3, ^DAG, ˇK+ conductance
alpha2-> g-protein: ˇcAMP
beta1 -> g-protein:^ cAMP
what increases norepinephrine release?
what decreases norepinephrine release?
what decreases norepineprhine reuptake?
what decreases the rate of norepinephrine metabolism?
what receptors are associated to serotonin and what are their mechanisms?
5HT1a- G-protein: ˇcAMP, ^K+
5HT2a- G-proteinL ^IP3, ^DAG, ˇ K+
what increases serotonin release?
what decreases the reuptake of serotonin?
what decreases the metabolism of serotonin?
what is a 5-HT2a partial agonist?
what is a 5-HT2A antagonist?
what reduced [neurotransmission] is linked to depression?
what is an mu agonist? And what drug is it linked to?
heroin, morphine, methadone
what is a my antagonist?
what receptor is prefered for olanzapine?
what receptor is preferred for haloperidol?
what does bupropion do?
mechanism not clearly understood, but it weakly inhibits reuptake and stimulates release of NE and dopamine