CNS Drug List Flashcards Preview

BIOM*3090. UOG > CNS Drug List > Flashcards

Flashcards in CNS Drug List Deck (38):
1

what is the glutamate receptor and what is its mechanism?

NMDA and ^ Ca2+, Na2+, K+ conductance

2

what drugs decrease NMDA release?

morphone, heroin, and THC

3

what drugs decrease NMDA receptor activation

PCP
Ethanol

4

What are the two receptors associated with Acetylcholine?

M and N

5

what is the mechanism of Acetycholine?

G-protein linked: ^ IP3, ^ DAG, and decrease K+ conductance
Ion channels: ^ Na+, K+ conductance

6

what is a direct agonist for acetylcholine, and an antagonist?

agonist: donepezil
antagonist: benztroine

7

what are two inhibitory neurotransmitters?

GABA and Dopamine

8

what are the two GABA receptros, and what is the mechanism of GABA?

a and b
ionchannel: ^ CL- conductance
G-protein: ^K+conductance

9

what decreases the release of GABA?

THC, morphine and Heroin

10

what do these 3 drugs do?
dizapam
phenobartial
ethanol?

Increase GABAa receptor activation

11

what is the receptor and mechanism of Dopamine?

D2
Presynatic: G-protein -> decrease Ca+2 conductance
postsynaptic: G-protein -> ^ K+ conducntance and decrease cAMP

12

what drug increases dopamine synthesis?

L-DOPA

13

what drug increases dopamine release?

amphetamine

14

what drug decreases dopamine reuptake?

cocaine

15

what drug decreases dopamine metabolism?

phenelzine and selegiline

16

what is a D2 agonist?

ropinirole

17

what is a D2 antagonist?

haloperiode
olanzapine

18

what is the cause of AD? (alzheimers Disease)

loss of cholinergic projection neurons,

19

what is the cause of Parkinsons Dieaseas?

loss of nigro-striatal dopamine projection neurons

20

how is dopamine linked to psychosis and schizophrenia?

excess dopamine neurotransmission in limbic system

21

name the 3 receptors and linked mechanism to norepinephrine

alpha1-> g-protein: ^IP3, ^DAG, ˇK+ conductance
alpha2-> g-protein: ˇcAMP
beta1 -> g-protein:^ cAMP

22

what increases norepinephrine release?

amphetamine
tyramine

23

what decreases norepinephrine release?

morphine
heroine

24

what decreases norepineprhine reuptake?

imipramine
cocaine

25

what decreases the rate of norepinephrine metabolism?

phenelzine

26

what receptors are associated to serotonin and what are their mechanisms?

5HT1a- G-protein: ˇcAMP, ^K+
5HT2a- G-proteinL ^IP3, ^DAG, ˇ K+

27

what increases serotonin release?

amphetamine

28

what decreases the reuptake of serotonin?

imipramine
fluoxetine
cocaine

29

what decreases the metabolism of serotonin?

phenelzine

30

what is a 5-HT2a partial agonist?

LSD

31

what is a 5-HT2A antagonist?

haloperidol
olanzapine

32

what reduced [neurotransmission] is linked to depression?

monoamine

33

what is an mu agonist? And what drug is it linked to?

Opioids
heroin, morphine, methadone

34

what is a my antagonist?

naloxone

35

what receptor is prefered for olanzapine?

5-HT2a>D2

36

what receptor is preferred for haloperidol?

D2> 5-HT2z

37

what does bupropion do?

mechanism not clearly understood, but it weakly inhibits reuptake and stimulates release of NE and dopamine

38

how do methanol and ethanol mix?

methanol competes with ethanol for metabolism. ethanol is used to treat methanol overdose.**