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BIOM*3090. UOG > CNS-introduction > Flashcards

Flashcards in CNS-introduction Deck (25):
1

what components does the cortex control?

sensory
motor
thought process

2

what components does the limbic system control?

emotion/memory

3

what component does the diencephalon control?

endocrine/ autonomic

4

what component does the cerebellum control?

sensory/ motor co-ordination

5

what component does the midbrain/brain stem control?

reflex pathways / information relay/ awareness/arousal

6

what component does the spinal cord control?

sensory / motor/ autonomic

7

what are interneurons?

communicate within same brain region

8

what are projection neurons?

axons project from one brain region to another

9

What is neurodegenerative disease / CNS disorders?

an imbalance in neurotransmission
drugs attempt to restore the balance.

10

what are the 4 classifications of transmitters?

1. amino acids (excitatory- glutamate, inhibitory- GABA)
2. acetylcholine
3. monoamines (dopamine, Norepinephrione, serotonin)
4. peptides

11

how dose glutamate effect the CNS?

it relays neurons, and acts on NMDA and non-NMDA receptors.

12

what is an NMDA receptor?

its an ion channel ( ^ [Ca2+], [Na+], [K+])

13

how dos GABA effect the CNS?

associated with the behaviour, acts on postsynaptic GABA receptors.

14

what is GABAa

ion channel linked to (^ [Cl-])
and is the target for sedative hypnotics

15

what is GABAb

G-protein linked to ion channel ( ^[K+])

16

how is acetylcholine associated with the CNS?

interneurons: associated with motor control
Projection: associated with learning, memory and congition

acts on muscarinic and nicotinic receptors.

17

how is norepinerphrine associated with the CNS?

throughout CNS and important in awareness/arousal/ autonomic control.
alpha 1 & beta 1 : excitatory
alpha 2 & beta 2: inhibitory

18

how is dopamine associated with CNS?

cortex: motivation/emotion
limbic: mood/behaviour
midbrain: motor control
there are 5 subtypes of dopamine receptors (D1-D5) linked to G-protein second messenger system.

19

how is serotonin associated with CNS?

play role in behaviour and control of sleep, temperature, appetite, and neuroendocrine function.
14 subtypes, all linked to G- protein secondary messengers

catergories 5-HT1 to 5-HT7, subtypes indicated by letter

20

what does 5-HT1a and 5-HT2a do?

5-HT1a: inhibitory - decreases cAMP
5-HT2a: excitatory, ^DAG, IP3

21

how does transport occur for the BBB?

transport occurs primarily via passive diffusion. therefore the diffusion dependent on drug lipid solubility and pKA

22

what are the symptoms for AD? (alzheimers disease)

progressive and irreversible memory loss and cognitive impairment

23

how is AD diagnosed?

if neurofirillary tangles and amyloid plaques are present in hippocampus and cortex

24

what are tangles and plaques in the brain?

tangles: intracelluylar accumulation of twister fibers of phosphorylated tau protein
plaques= extracellular deposits of beta- amyloid protein.

25

that is the treatment for AD?`

no cure, treatment is aimed to prevent/ reverse the plaque and tangle formation.
- acetycholinesterase inhibitors