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BIOM*3090. UOG > CNS-Alcohol > Flashcards

Flashcards in CNS-Alcohol Deck (5)
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1

what are the acute effects of ethanol on the CNS system?

dose-dependent CNS depression (ˇ membrane excitability + ^GABAa & ˇ NMDA acivation)
diuresis
ˇ myocardial contractility
ˇ anxiety, slurred speech, impaired judgement

toxic doses: CNS and respiratory depression.

2

what are the chronic effects of ethanol on the CNS system?

fatty liver->hepatitis-> cirrhosis ->liver failure
pancreatits & gastritis
malnutrition

3

how is ethanol eliminated from the human body?

>90% is metabolized by the liver (oxidation)

4

what is methanol, and how is it metabolized?

wood alchohol
methanol metabolism -> formic acid -> blindness

5

how do you treat methanol consumption?

ethanol. it has a higher affinity for alcohol dehydrogenase therefore it slows methanol metabolism to formic acid