CNS Drugs

Question 1

Tricyclic Antidepressants

Answer 1

Nortriptyline
Amitriptyline
Imipramine
Desipramine
Clomipramine

Question 2

MOA: TCAs

Answer 2

Inhibit the reuptake of NE>SE
Antimuscarinic
Antihistamine
Alpha-blocking effect

Question 3

AE: TCAs

Answer 3

Sedation
Orthostatic hypotension
Anticholinergic effect
Weight gain
Cardiotoxicity (QT Prolongation)

Question 4

Uses: TCAs

Answer 4

Mx of depression
Mx of OCD (Clomipramine)
Mx of neuropathic pain
Mx of enuresis (Imipramine)

Question 5

Tetracyclic antidepressants

Answer 5

Mianserin
Amoxapine
Maprotiline

Question 6

Non-selective MAOIs

Answer 6

Phenelzine
Isocarboxazid
Tranylcypramine

Question 7

MAO-A inhibitor

Answer 7

Moclobemide

Question 8

MAO-B inhibitor

Answer 8

Selegiline

Rasagiline

Question 9

Drug Interactions: MAOIs

Answer 9

Tyramine
Ephedrin
Amphetamine
Cocaine
Phenylpropanolamine —> Hypertensive crisis

Serotonergic agents: SSRIs and Venlafaxine
Consequence: Serotonin syndrome
(Mx: Cyproheptadine)

Question 10

Serotonin Antagonists

Answer 10

Mefazodone

Trazodone

Question 11

AE of Mefazodone

Answer 11

Hepatotoxicity

Question 12

AE: Trazodone

Answer 12

Sedation

Off label use: Mx of insomnia and Priapism

Question 13

Reversible inhibitor of MAO-A (RIMA)

Answer 13

Moclobemide

Question 14

Noradrenaline Reuptake Inhibitor (NaRI)

Answer 14

Reboxetine

Question 15

Serotonin-NE Reuptake Inhibitor

Answer 15

Duloxetine
Venlafaxine
Desvenlafaxine

Question 16

Selective Serotonin Reuptake Inhibitor

Answer 16

Fluoxetine
Fluroxamine

Sertraline
Paroxetine
Escitalopram
Citalopram

Question 17

Mx of Bulimia

Answer 17

Fluoxetine

Question 18

Noradrenergic Specific Antidepressant

Answer 18

Mirtazapine

MOA: presynaptic alpha-2 inhibition ——> Increase release of NE

Question 19

Norepinephrine-Dopamine Reuptake Inhibitor

Answer 19

Bupropion- smoking cessation

Question 20

MOA: Lithium

Answer 20

Inhibits recycling of Phosphoinositides ——> IP3, DAG

Question 21

Use: Lithium

Answer 21

First line in the management of mania

Question 22

AE: Lithium

Answer 22

Polyuria
Polydipsia
Nausea
Fine tremors

Question 23

Toxicity: Lithium

Answer 23

Coarse tremors
Seizures
Hyper-reflexia

Question 24

Increases Lithium Concentration

Answer 24

Sodium loss
ACEIs
NSAIDS
Thiazide diuretics

“SlANT”

Question 25

Decreases Lithium concentration

Answer 25

Acetazolamide Xanthines Osmotic diuretics Na supplements “AXON”

Question 26

An enzyme inhibitor used in the Mx of Mania, rapid recycling and mixed disorders

Answer 26

Valproic acid

Question 27

AE: Valproic acid

Answer 27

Hepatotoxicity CI: < 2 y.o

Question 28

An enzyme inducer that is used in the tx and prevention of Mania

Answer 28

Carbamazepine

Question 29

Atypical Antipsychotics

Answer 29

``` Ziprasidone Aripiprazole Risperidone Olanzapine Quetiapine ```

Question 30

MOA: Benzodiazepines

Answer 30

Increase frequency of Cl-channel opening

Question 31

Short acting BZDs

Answer 31

Midazolam | Triazolam

Question 32

Intermediate-acting BZDs

Answer 32

Temazepam Alprazolam Lorazepam Oxazepam “TALO”

Question 33

Long-acting BZDs

Answer 33

``` Clonazepam Clorazepate Chlordiazepoxide Diazepam Halazepam ```

Question 34

First-line Mx of Status epilepticus

Answer 34

IV Lorazepam IV Diazepam IM Midazolam

Question 35

2nd line Seizure disorders

Answer 35

``` Valproic acid (IV) Fosphenytoin (IV) ```

Question 36

3rd line: Seizure

Answer 36

Thiopental | Propofol

Question 37

MOA: Barbiturates

Answer 37

Increase duration of Cl-channel opening

Question 38

Ultra-short acting barbiturates

Answer 38

Thiopental Thiamylal Methohexital

Question 39

Short-acting Barbiturates

Answer 39

Pentobarbital Secobarbital Hexobarbital

Question 40

Intermediate-acting Barbiturates

Answer 40

Amobarbital | Butabarbital

Question 41

Long-acting Barbiturates

Answer 41

Phenobarbital | Barbital

Question 42

Other: Barbiturates

Answer 42

Ramelteon- Mx of Insomnia, melatonin receptor agonist (MT1/MT2)

Question 43

Tx of Partial Seizure

Answer 43

Carbamazepine | Phenytoin

Question 44

Type of Partial seizure where there is no loss of consciousness

Answer 44

Simple Partial

Question 45

Type of Partial seizure where there is loss of consciousness

Answer 45

Complex partial

Question 46

Generalized Tonic-Clonic is also known as

Answer 46

Grand mal

Question 47

Aka Petit mal

Answer 47

Absence seizures

Question 48

Tx of Generalized-Tonic Clonic

Answer 48

Valproic acid Alternative: Phenytoin and Carbamazepine

Question 49

Tx of Absence seizures

Answer 49

Ethosuximide | Valproic acid

Question 50

Loss of muscle tone

Answer 50

Myoclonic and Atonic seizures

Question 51

Tx of Myoclonic and Atonic seizures

Answer 51

Valproic acid | Clonazepam

Question 52

GABA-ergic

Answer 52

``` BZDs BRBs Gabapentin Tiagabine Vigabatrin ```

Question 53

Glutamate receptor antagonists

Answer 53

Felbamate | Topiramate

Question 54

Na channel blockers

Answer 54

Phenytoin Carbamazepine Oxcarbazepine Zonisamide

Question 55

Ca channel blockers

Answer 55

Ethosuximide (T-type) | Levetiracetam (N-Type)

Question 56

K channel

Answer 56

Reltagabine