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Flashcards in CNS Infections Deck (23):
1

What are the 4 questions to ask in CNS infections?

Is this acute or Chronic?
What is the Etiology?
What workup is needed?
What is the required Treatment?

2

What is the most severe type of meningitis?

Acute Bacterial Meningitis

3

What are the non-infectious etiologies for CNS signs?

Neoplasia
Collagen Vascular Disease
Medications(Bacterim or Cipro)

4

What is the best way to diagnose a CNS infection?

CSF sample that isn't contaminated by Abtx
Glucose level of the CSF (compare to Serum glucose: ratio of .6)

5

Why should you get a Lumbar puncture before giving Abtx?

It will give you a false negative on Gram stain

6

What is the appearance of CSF if there is an infection?

Yellow color

7

What is seen in a bacterial infection?

Lower GLucose
Higher WBCs
High Protein Content
Neutrophils

8

Who should get neuroimaging studies?

Persistant or prolonged fever
Focal or neuro findings
Evidence of ICP
New or Recurrent Seizures
Persistant Neuro Dysfunction
Persistent abn CSF parameters or cultures
Enlarging Head Circ in neonates

9

How should we choose an antibiotic?

Crosses BBB
Don't give bacterostatic agent

Give steroids to counteract swelling

10

What is the cutoff for Low/High GLucose in CSF?

+/- 40mg/dL

11

What are the most common Bacterial causes of Meningitis?

Strep Pneumo
Neisseria Meningitidis

12

What are the most common Viral causes of Meningitis?

Enterovirus
Herpes Viruses

13

What are the Bacterial Microbes that can cause Chronic Meningitis?

TB
Treponema Pallidum
Borrelia Burgdorpheri

14

What is the the Reccomended Therapy for Acture Bacterial Meningitis?

Ceftriaxone
(AMpicillin for Lysteria or GBS)
Add Vanco if Strep Pneumo

15

What pathogen is common in plate or device installation?

Coaguulase Negative Staph

16

What is used to treat Acute Bact. meningitis in an immunocomprimized state?

Vanco + Ampicillin + Cefpime or Meropenem

17

What is used to treat Acute Bact. meningitis in a basilar skull fracture?

Vanco + 3rd Gen Cephalosporin

18

What is used to treat Acute Bact. meningitis in an Head Trauma/neuro surgery?

Vanco + Ceftazidime/cefpime/meropenem

19

What is used to treat Acute Bact. meningitis in an If patient is less than 1 month old?

Ampicillin + Cefotaxime

20

Who is a good candidate for steroids?

Strep Pneumo
Dexamethasone

21

WHat area of the country is affected by Lyme disease?

Great lakes area, Upstate New york

22

WHat are the stages of Lyme disease?

Bullseye rash
Myocarditis and Bell's Palsy
Migratory Polyarthritis and Encephalopathy

23

What is the Tx of Lyme Disease?

Ceftriaxone