Congenital Infections Flashcards Preview

Infectious Disease > Congenital Infections > Flashcards

Flashcards in Congenital Infections Deck (25):
1

What are the TORCHES infections?

Toxoplasmosis
Rubella
CMV
Herpes/Hepatitis
Syphilis

2

What is the common presentation for most TORCHES infections?

SGA or IUGR
Thrombocytopenia
Hepatosplenomegaly
Jaundice
Microcephaly

3

How can Toxoplasma gondii be acquired?

Cat Feces
Undercooked meat
Undercooked eggs
Unpasteurized milk

4

What is the most common clinical finding in Congenital Toxoplasmosis?

Chorioretinitis
Intracranial Calcification
Hydocephalus

5

What is chorioretinitis?

Inflammationof the posterior portion of the uvea tract and retina
Manifest later as Blurry vision, retinal detachment, glaucoma

6

Where are intracranial Calcifications?

Caudate nucleus
Choroid Plexus
Meninges
Subpendyma

PeriVentricular most classic for cmV

7

How is Toxoplasmosis diagnosed?

Serum IgM titers or persistent IgG
Optho exam
Neuro Exam
Head CT
LP (Toxo PCR)

8

What are the most common outcomes in Toxoplasmosis Infections?

Mental Retardation
Seizures

9

How is rubella transmitted?

Vertical Transmission or respiratory droplets
(German Measles)

10

What are the most common presentations of Congenital Rubella Syndrome?

Patent Ductus Arteriosus
Deafness
Cataracts

11

How is Rubella Treated?

Reverse Transcriptase PCR
Serum IgM
Rise in IgG titer over 2-3 weeks
Culture

12

What is the most common congenital infection in developed countries?

Cytomegalovirus

13

How is CMV transmitted?

Infected secretions
Vertically
Transfusion

14

Infection with CMV in which semester leads to the worst sequelae?

1st trimester.

15

What are the most common findings in CMV?

Petechia/Ecchymosis
Jaundice at birth or within a few hours
Hepatosplenomegaly

16

What causes the charicteristic Bluberry muffin rash in CMV?

Erythropoesis occurring in the skin, not the BM.

17

Where are Intracranial Clcifications seen in cmV?

PeriVentricular

18

How is CMV diagnosed?

Urine CMV culture
Serum IgM titers
Head CT

19

What is the Treatment for CMV?

Gancyclovir possibly

20

What are the non-congenital manifestations of HSV?

Genital Herpes
Gingivostomatitis
Conjunctivitis
Encephalitis
Eczema Herpeticum

21

What are the physical Findings in HSV?

SEM (Skin, Eye, mouth)
Irritability
Lethargy
poor feeding
tremulousness
seizures

22

How is HSV Diagnosed?

Culture
CBC, LFT
PCR

23

How is Congenital HSV transmitted?

Ask preggo women about history of herpes and active lesions
C-Section if they have active lesions
Cultures on newborns
Tx with Acyclovir

24

What is the Tx for Congenital Syphilis?

Penicillin?

25

What are the Stages of Syphilis?

1^: Painless, genital ulcer
2^: Rash
Fever, malaise, LAD, Condyloma lata
Latent
3^: Gumma, bone/skin/visceral changes
Neurosyphilis at any stage