Flashcards in Viral infections Deck (23):
WHat are the Most common Herpes viruses?
What is the pathogenesis of Herpes Simplex virus infection?
Viral seeds a ganglion
Spreads via peripheral nerves
What is caused by HSV-1?
Immcomp: Genital, liver, lung, eye, CNS
What is caused by HSV-2?
75-80% of recurrent genital herpes infections.
What is charicteristic of Primary vs Reactivation of HSV infection?
Primary: Sudden, Asymptomatic, painful lesions
Reactivation: Systemic S and S, Local Lymphadenopathy
Prodromal Symptoms: Pain, burning, tingling, pruritis
What are the opthalmologic manifestations of HSV?
What are the CNS Manifestations of Herpes?
Herpes Simplex Encephalitis (temporal lobe)
Molaret Syndrome:(recurrent meningitis associated with reactivation of HSV)
Transverse myelitis/Sacral autonomic Dysfunction
What are the visceral infections of HSV?
Pneumonitis, Hepatitis rare
What is seen in HSV infection of immunocomprimized?
More frequent recurrence
Visceral infection = High mortality
How is HSV diagnosed?
Tzanck Smear (multinucleated giant cells)
What is the Tx of HSV?
Eye infections- Topical antivirals
What are the traits of Varicella Zoster infection?
More serious in adults
Aerosolized droplets from nasopharynx or direct contact from vesicle fluid
How do you know that someone with Varicella Zoster is no longer contageous?
All their Sores are crusted over
What are the risk factors for Varicella Pneumonia?
Smoking, pregnanacy, immuosupression
What is the Tx of Varicella?
VZV less suceptible to Acyclovir than HSV but still first line
WHo should recieve the VZV vaccine?
Ongoing risk of exposure
immsupressed Pts in household
Women of Childbearing age
Post exposure prophylaxis in non-immune Pts of children with pox
Outbreaks with intense exposure
WHat are the different manifestations of Herpes Zoster infection?
Acute Neuritis and Post-Herpetic Neuralgia
Ocular: Acute retinal necrosis
What is the Tx for Zoster?
Vaccine to avoid shingles
What will happen if you give aspirin to a Zoster patient?
What is the manifestation of EBV in adolescents and adults ?
What are the malignancies associated with EBV?
What is the the Tx of EBV?
Avoid Contact sports
Steroids when there's airway obs, aplastic anemia, fulminant hepatitis