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Flashcards in Viral infections Deck (23):
1

WHat are the Most common Herpes viruses?

HSV

2

What is the pathogenesis of Herpes Simplex virus infection?

Viral seeds a ganglion
Spreads via peripheral nerves

3

What is caused by HSV-1?

Herpes Labialis
Immcomp: Genital, liver, lung, eye, CNS

4

What is caused by HSV-2?

75-80% of recurrent genital herpes infections.

5

What is charicteristic of Primary vs Reactivation of HSV infection?

Primary: Sudden, Asymptomatic, painful lesions
Reactivation: Systemic S and S, Local Lymphadenopathy
Prodromal Symptoms: Pain, burning, tingling, pruritis

6

What are the opthalmologic manifestations of HSV?

Necrotizing Retinitis
HSV Keratitis

7

What are the CNS Manifestations of Herpes?

Herpes Simplex Encephalitis (temporal lobe)
Aseptic Meningitis
Molaret Syndrome:(recurrent meningitis associated with reactivation of HSV)
Transverse myelitis/Sacral autonomic Dysfunction
Bell's Palsy

8

What are the visceral infections of HSV?

HSV Esophagitis
HSV Tracheitis
Pneumonitis, Hepatitis rare

9

What is seen in HSV infection of immunocomprimized?

More frequent recurrence
Disseminated infection
Visceral infection = High mortality

10

How is HSV diagnosed?

Clinical Diagnosis
Culture/PCR
Tzanck Smear (multinucleated giant cells)

11

What is the Tx of HSV?

Acyclovir
Foscarnet, Gancyclovir
Eye infections- Topical antivirals

12

What are the traits of Varicella Zoster infection?

Highly COntageous
More serious in adults
Aerosolized droplets from nasopharynx or direct contact from vesicle fluid

13

How do you know that someone with Varicella Zoster is no longer contageous?

All their Sores are crusted over

14

What are the risk factors for Varicella Pneumonia?

Smoking, pregnanacy, immuosupression

15

What is the Tx of Varicella?

VZV less suceptible to Acyclovir than HSV but still first line

16

WHo should recieve the VZV vaccine?

Ongoing risk of exposure
immsupressed Pts in household
Women of Childbearing age
Post exposure prophylaxis in non-immune Pts of children with pox
Outbreaks with intense exposure

17

WHat are the different manifestations of Herpes Zoster infection?

Cutaneous
Acute Neuritis and Post-Herpetic Neuralgia
Ocular: Acute retinal necrosis
Oticus(ears)
CNS
Pneumonitis
Hepatitis

18

What is the Tx for Zoster?

Acyclovir #1
Valacyclovir
Famcyclovir

Vaccine to avoid shingles

19

What will happen if you give aspirin to a Zoster patient?

Reye's Syndrome

20

What is the manifestation of EBV in adolescents and adults ?
Children?

Infectious Mononucleosis
Subclinical

21

What are the malignancies associated with EBV?

Lymphoproliferative disorders
Duncan Syndrome
Burkitt's Lymphoma
Nasopharyngeal CA
Hodgkin's dis
T-cell lymphoma
Nasal Lymphoma

22

What is the the Tx of EBV?

Supportive Care
Avoid Contact sports
Steroids when there's airway obs, aplastic anemia, fulminant hepatitis

23

What is seen on microscopy of CMV?

Owl Eye inclusions