CNS neurotransmitters Flashcards Preview

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Flashcards in CNS neurotransmitters Deck (23):
1

CNS neurotransmitters - types

1. Norepinephrine 2. Dopamine 3. 5-HT
4. ach 5. GABA

2

norepinephrine - change in disease

increased in anxiety
decreased in depression

3

norepinephrine - location of synthesis in CNS

Locus ceruleus (pons)

4

Dopomine - change in disease

increased in Huntington
decreased in Parkinson
decreased in depression
increased in Schizophrenia

5

Dopamine - location of synthesis in CNS

ventral tegmentum AND substantia nigra pars compacta (midbrain)

6

5-HT - change in disease

Decreased in anxiety
decreased in depression
INCREASED IN PARKINSON

7

5-HT - location of synthesis

Raphe nuclei (pons, medulla, midbrain)

8

ACH - change in diseases

increased in Parkinson
decreased in Alzheimer
decreased in Huntington

9

ACH - location of synthesis in CNS

Basal nucleus of Meynert

10

GABA - change in disease

decreased in anxiety
decreased in Huntington

11

GABA -location of synthesis in CNS

Nucleus accumbens

12

Locus ceruleus synthesize ... and is responsible for

norepinephrine
stress and panic

13

reward center consits of

Nucleus accumbens and septal nucleus

14

reward center is responsible for

pleasure, fear, addiction

15

substances that stimulate reward center (and action)

endocannabinoids --> increase desire for high-fat foods

16

anxiety - changes in neurotransmitters

increased norepinephrine
decreased 5-HT and GABA

17

depression - changes in neurotransmitters

decreased norepinephrine, dopamine and 5-HT

18

Huntington disease -changes in neurotransmitters

decreased GABA, ACH
increased dopamine

19

Parkinson disease - changes in neurotransmitters

decreased dopamine
increased ACH
INCREASED SERETONIN

20

Alzheimer disease - changes in neurotransmitters

decreased ACH
increased glutamate

21

locus coeruleus is a .... (area and function)

nucleus in the pons involved with physiological responses to stress and panic.
(υπομέλαν τόπος)

22

Schizophrenia - changes in neurotransmitters

increased dopamine

23

CNS neurotransmitters - types and location of synthesis

1. Norepinephrine --> Locus ceruleus
2. Dopamine --> Ventral tegmentum, substantia nigra pars compacta (midbrain)
3. 5-HT --> Raphe nucleis
4. ach --> Basal nucleus of Meynert
5. GABA --> Nucleus accumbens