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Flashcards in CNS Trauma Intro Deck (15)
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0

Most important thing astrocytes do

react to injury

1

Most important thing oligodendrocytes do

produce myelin

2

Most important thing microglia do

phagocytose intruders

3

Most important thing ependymal cells do

Line ventricles

4

How do astrocytes differ from oligodendrocytes on an H&E stain?

Astrocytes are bigger and generally have looser chromatin. Oligodendrocytes have a staining free halo around them

5

What do neurons look like that have undergone acute injury?

turn red in stain

6

Chronic injury results in what kind of damage to a neuron?

degeneration

7

What is axonal reaction?

when axons are severed off of neurons and the cell body swells

8

What are axonal spheroids?

When a part of the axon stains darker, indicating damage to the axon.

9

Cowdry bodies are found in neurons that are...

Infected with herpes

10

Negri bodies are found in cells that are...

infected with rabies

11

Things astrocytes do to respond to injury

Gliosis (astrocytic proliferation)
•Gemistocytic astrocytes
•Cytoplasmic swelling
•Inclusion bodies
•Rosenthal fibers
•Corpora amylacea

12

Rosenthal fibers are...

thick, elongated, worm-like or "corkscrew" eosinophilic bundle that is found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders. Have ubiquitin

13

Corporea Amylacia is...

Changes that happen in astrocytes that have a bigger, rounder appearance. Look like pearls. Just a degenerative change that you see in aging. don't mean anything, but shouldn't be confused with a tumor

14

What do microglia do when responding to injury?

Proliferate, develop long nuclei, form nodules around dead cells