Coag Study Guide

Question 1

What is the normal value for Duke bleeding time?

Answer 1

1-3 minutes - earlobe

Question 2

What is the normal value for Ivy bleeding time?

Answer 2

less than 10 minutes - forearm

Question 3

What is the normal value for the template bleeding time?

Answer 3

standard, outdated. ASK

Question 4

Aspiring causes a prolonged bleeding time due to ?

Answer 4

inhibits platelet aggregation

Question 5

Interpret results on Thrombo Wellco agglutination test

Answer 5

10 40 mcg/mL

1:20

Question 6

Fibrinolysis depends upon the conversion on ? in the plasma to the active form of ?

Answer 6

plasminogen

plasmin

Question 7

Clot lysis is a test for ? and takes ? hours

Answer 7

Fibrinolysis

72

Question 8

A more rapid clot test for lyisis is ? and takes ? hours

Answer 8

euglobulin

2

Question 9

Primary fibrinolysis is difficult to distinguish from secondary because?

Answer 9

Primary usually decreased but still in normal range

Secondary (DIC) greatly decreased because they are consumed by clotting

Question 10

PBS in primary and secondary

Answer 10

Primary - normal

Secondary - schistocytes due to effect of clotting on rbc/s

Question 11

Four stages of coagulation

Answer 11

formation of thromboplastin
conversion of prothrombin to thrombin
conversion of fibrinogen to fibrin
fibrinloysis due to thrombin

Question 12

Why are the PT and PTT good choices for coag testing?

Answer 12

Simple
relatively short time
tests for all factors
share one tube

Question 13

Besides PT and PTT, what test is a good choice for coag testing?

Answer 13

Bleeding time

quick and checks platelet function

Question 14

Why is the clotting time test not a good choice for coag test?

Answer 14

inconvenient
drawn with syringe
performed immediately

Question 15

What vascular disorder is related to thrombasthenia

Answer 15

normal, abnormal function

Question 16

What vascular disorder is related to thrombocytopenia?

Answer 16

decreased, normal function

Question 17

What vascular disorder is related to thrombocythemia?

Answer 17

increased, abnormal function

Question 18

What vascular disorder is related to telangiectasia?

Answer 18

Hereditary vascular abnormality

Question 19

What vascular disorder is related to thrombocytosis?

Answer 19

increased, normal function

Question 20

What factor deficiency causes a prolonged thrombin time

Answer 20

Fibrinogen (I)

Question 21

What factors increase PT?

Answer 21

I
II
V
VII
X

Question 22

What factors increase PTT?

Answer 22

VIII
IX
XI
X
V
II
I

Question 23

Which factors increase both PT and PTT?

Answer 23

I
II
V
X

Question 24

Which are labile factors and how are deficiencies treated?

Answer 24

V
VIII
fresh blood or FFP

Question 25

Which test is performed to differentiate vWD from Hemophilia A

Answer 25

Bleeding time- both involve VIII deficiency | PT - increased but vWD has plt abnormality

Question 26

What will correct a PT due to deficiency of Factor VII

Answer 26

Russell's Viper Venom (stypven)

Question 27

What is the initial plug on the wall of a vessel comprised of initially and then replaced by

Answer 27

platelets replaced by fibrin

Question 28

Patelet Factor 3 is required for which system of coagulation

Answer 28

Intrinsic | source of phospholipid

Question 29

What is the normal platelet count

Answer 29

150,000-400,000

Question 30

At what plt count will bleeding occur

Answer 30

below 50,000 | usually in form of petechiae and scchymoses

Question 31

Anticoagulant for PT and PTT

Answer 31

sodium citrate

Question 32

Ratio of blood to anticoagulant in PT and PTT

Answer 32

9:1 low Hct - too much anticoag high Hct - needs More anticoag

Question 33

Liver Factors

Answer 33

``` I II V VII IX X ```

Question 34

Vitamin K dependent

Answer 34

II VII IX X

Question 35

Absorped plasma factors

Answer 35

V VIII IX X

Question 36

Aged serum

Answer 36

``` VII IX X XI XII ```

Question 37

What is the PTT used for

Answer 37

monitor intrinsic pathway | heparin therapy

Question 38

What is the PT used for

Answer 38

monitor extrinsic pathway | coumadin therapy

Question 39

What other tests may be used to monitor heparin therapy

Answer 39

Lee White clotting time | TT

Question 40

What test is used for Factor XIII

Answer 40

5M urea solubility

Question 41

The extrinsic system is initiated by

Answer 41

tissue factor III

Question 42

The intrinsic system is initiated by

Answer 42

exposure to collagen activation of contact factor XII plt factor III

Question 43

What will interfere with synthesis of Vit K dependent factors

Answer 43

Coumadin

Question 44

What substance works with anti-thrombin III to neutralize thrombin

Answer 44

Heparin

Question 45

Antidote for heparin

Answer 45

protamine sulfate

Question 46

What is the principle of the fibrometer

Answer 46

completion of an electrical circuit between 2 electrodes by formation of a clot

Question 47

What is the principle of the Coagulyzer, Coag-A-mate, MLA

Answer 47

detection of optical density changes in a cuvet by the photocell when clot is formed

Question 48

Bleeding time test, what is it used for and is it performed

Answer 48

assess plt function and ability to form a clot | make a puncture wound in the superficial area and monitor the time needed to stop

Question 49

Clot retraction, what it's used for and what conditions does it indicate?

Answer 49

Fibrinogen and Hct must be normal measures time for clot to lyse 0-2 hours thrombocytopenia and Glanzmanns thrombasthenia

Question 50

Which factors have an enzymatically active form

Answer 50

not V, VII, XIII

Question 51

What is used in substitution testing

Answer 51

absorped plasma and aged serum | pinpoints factor deficiencies

Question 52

How is sunstitution testing done

Answer 52

prior to testing with reagents, sample should be mixed with normal plasma and deficiency corrected. If not, a circulating anticoag should be suspected

Question 53

Overall competence check of coag system would include

Answer 53

``` PT PTT bleeding time clot solubility test (XIII) fibrinogen ```

Question 54

Haemans

Answer 54

XII

Question 55

Christmas

Answer 55

IX

Question 56

Stuart Power

Answer 56

X

Question 57

Hemophilia A

Answer 57

VIII

Question 58

Parahemophilia

Answer 58

V

Question 59

Fibrinolysis depends on action of ? ?

Answer 59

plasmin

Question 60

What is the coag test for fibrinolysis

Answer 60

euglobulin lysis est

Question 61

First stage of coag

Answer 61

Plasma thromboplastin

Question 62

Prolonged PTT indicated deficiency of ? ?

Answer 62

Fibrinogen

Question 63

How ia anticoag adjusted if Hct is 55% or more

Answer 63

Increase volume

Question 64

abnormal PT, normal PTT

Answer 64

VII

Question 65

normal PT, abnormal PTT

Answer 65

IX

Question 66

normal BT, abnormal clotting, normal PT, abnormal PTT

Answer 66

VIII