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MLT Clinical Practicums > Coag Study Guide > Flashcards

Coag Study Guide Flashcards

1
Q

What is the normal value for Duke bleeding time?

A

1-3 minutes - earlobe

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2
Q

What is the normal value for Ivy bleeding time?

A

less than 10 minutes - forearm

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3
Q

What is the normal value for the template bleeding time?

A

standard, outdated. ASK

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4
Q

Aspiring causes a prolonged bleeding time due to ?

A

inhibits platelet aggregation

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5
Q

Interpret results on Thrombo Wellco agglutination test

A

10 40 mcg/mL

1:20

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6
Q

Fibrinolysis depends upon the conversion on ? in the plasma to the active form of ?

A

plasminogen

plasmin

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7
Q

Clot lysis is a test for ? and takes ? hours

A

Fibrinolysis

72

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8
Q

A more rapid clot test for lyisis is ? and takes ? hours

A

euglobulin

2

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9
Q

Primary fibrinolysis is difficult to distinguish from secondary because?

A

Primary usually decreased but still in normal range

Secondary (DIC) greatly decreased because they are consumed by clotting

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10
Q

PBS in primary and secondary

A

Primary - normal

Secondary - schistocytes due to effect of clotting on rbc/s

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11
Q

Four stages of coagulation

A

formation of thromboplastin
conversion of prothrombin to thrombin
conversion of fibrinogen to fibrin
fibrinloysis due to thrombin

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12
Q

Why are the PT and PTT good choices for coag testing?

A

Simple
relatively short time
tests for all factors
share one tube

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13
Q

Besides PT and PTT, what test is a good choice for coag testing?

A

Bleeding time

quick and checks platelet function

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14
Q

Why is the clotting time test not a good choice for coag test?

A

inconvenient
drawn with syringe
performed immediately

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15
Q

What vascular disorder is related to thrombasthenia

A

normal, abnormal function

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16
Q

What vascular disorder is related to thrombocytopenia?

A

decreased, normal function

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17
Q

What vascular disorder is related to thrombocythemia?

A

increased, abnormal function

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18
Q

What vascular disorder is related to telangiectasia?

A

Hereditary vascular abnormality

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19
Q

What vascular disorder is related to thrombocytosis?

A

increased, normal function

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20
Q

What factor deficiency causes a prolonged thrombin time

A

Fibrinogen (I)

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21
Q

What factors increase PT?

A 
I
II
V
VII
X
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22
Q

What factors increase PTT?

A 
VIII
IX
XI
X
V
II
I
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23
Q

Which factors increase both PT and PTT?

A

I
II
V
X

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24
Q

Which are labile factors and how are deficiencies treated?

A

V
VIII
fresh blood or FFP

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25
Q

Which test is performed to differentiate vWD from Hemophilia A

A

Bleeding time- both involve VIII deficiency

PT - increased but vWD has plt abnormality

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26
Q

What will correct a PT due to deficiency of Factor VII

A

Russell’s Viper Venom (stypven)

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27
Q

What is the initial plug on the wall of a vessel comprised of initially and then replaced by

A

platelets replaced by fibrin

28
Q

Patelet Factor 3 is required for which system of coagulation

A

Intrinsic

source of phospholipid

29
Q

What is the normal platelet count

A

150,000-400,000

30
Q

At what plt count will bleeding occur

A

below 50,000

usually in form of petechiae and scchymoses

31
Q

Anticoagulant for PT and PTT

A

sodium citrate

32
Q

Ratio of blood to anticoagulant in PT and PTT

A

9:1
low Hct - too much anticoag
high Hct - needs More anticoag

33
Q

Liver Factors

A 
I
II
V
VII
IX
X
34
Q

Vitamin K dependent

A

II
VII
IX
X

35
Q

Absorped plasma factors

A

V
VIII
IX
X

36
Q

Aged serum

A 
VII
IX
X
XI
XII
37
Q

What is the PTT used for

A

monitor intrinsic pathway

heparin therapy

38
Q

What is the PT used for

A

monitor extrinsic pathway

coumadin therapy

39
Q

What other tests may be used to monitor heparin therapy

A

Lee White clotting time

TT

40
Q

What test is used for Factor XIII

A

5M urea solubility

41
Q

The extrinsic system is initiated by

A

tissue factor III

42
Q

The intrinsic system is initiated by

A

exposure to collagen
activation of contact factor XII
plt factor III

43
Q

What will interfere with synthesis of Vit K dependent factors

A

Coumadin

44
Q

What substance works with anti-thrombin III to neutralize thrombin

A

Heparin

45
Q

Antidote for heparin

A

protamine sulfate

46
Q

What is the principle of the fibrometer

A

completion of an electrical circuit between 2 electrodes by formation of a clot

47
Q

What is the principle of the Coagulyzer, Coag-A-mate, MLA

A

detection of optical density changes in a cuvet by the photocell when clot is formed

48
Q

Bleeding time test, what is it used for and is it performed

A

assess plt function and ability to form a clot

make a puncture wound in the superficial area and monitor the time needed to stop

49
Q

Clot retraction, what it’s used for and what conditions does it indicate?

A

Fibrinogen and Hct must be normal
measures time for clot to lyse 0-2 hours
thrombocytopenia and Glanzmanns thrombasthenia

50
Q

Which factors have an enzymatically active form

A

not V, VII, XIII

51
Q

What is used in substitution testing

A

absorped plasma and aged serum

pinpoints factor deficiencies

52
Q

How is sunstitution testing done

A

prior to testing with reagents, sample should be mixed with normal plasma and deficiency corrected. If not, a circulating anticoag should be suspected

53
Q

Overall competence check of coag system would include

A 
PT
PTT
bleeding time
clot solubility test (XIII)
fibrinogen
54
Q

Haemans

A

XII

55
Q

Christmas

A

IX

56
Q

Stuart Power

A

X

57
Q

Hemophilia A

A

VIII

58
Q

Parahemophilia

A

V

59
Q

Fibrinolysis depends on action of ? ?

A

plasmin

60
Q

What is the coag test for fibrinolysis

A

euglobulin lysis est

61
Q

First stage of coag

A

Plasma thromboplastin

62
Q

Prolonged PTT indicated deficiency of ? ?

A

Fibrinogen

63
Q

How ia anticoag adjusted if Hct is 55% or more

A

Increase volume

64
Q

abnormal PT, normal PTT

A

VII

65
Q

normal PT, abnormal PTT

A

IX

66
Q

normal BT, abnormal clotting, normal PT, abnormal PTT

A

VIII

MLT Clinical Practicums (12 decks)

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