MLT BB ABORh Flashcards
What immunoglobulin class is primarily associated with the antibodies of the ABO system?
IgM
IgG in type O
What is anti A1 lectin?
seed extract made from Dolichos biflorus which agglutinates A1, or A1B
What is the discrepancy? Possible causes?
antiA 4+ antiB 0 A1 2+ B 4+
Discrepancy is positive reaction with A1 cells. Due to: rouleaux cold alloantibody (M, P) A subgroups Cold autoantibodys (I, IH, H) Polyagglutination
Describe weak D.Explain why you use a control when testing for Du and what your do if the control is positive?
Normal D, but decreased amount
If Du control is positive, test is invalid. Investigation should be made as to why the control tube shows agglutination
What Rh type do you give a Du positive person?
Rh=, unless neonate or blood donor
Rh= Du= Rh control=
give Rh=
Rh+
give Rh +
Rh= Du+ Rh control +
invalid. If transfusion is necessary Rh neg can be given
Rh= Du+ Rh control=
Rh=
Rh+ for neonates
The H antigen is found in the highest concentration on what type of red blood cell?
type O
O>A2>B>A2B>A1>A1B
The lectin used for the detection of the H antigen is called:
Ulex europaeus
Type O
what phenotype would be compatible if the patient required a transfusion of RBC?
O
Type O
What phenotype would be compatible if the patient required a transfusion of FFP?
AB, O, A, B
opposite of rbc
Type O
What phenotype would be compatible if the patient required a transfusion of platelets?
AB, O, A, B for adults
neonates are type specific
neonate; less than 4 months
Is it possible for an Rh positive patient to have anti-D? Explain
Yes. D mosaic or D variant, known as partial D, antibodies are produced against missing epitopes.
Patients who receive WinRho, may be passive presumptive due to WinRho
