Coeliac disease

Question 1

What is coeliac disease?
When does it present?

Answer 1

Genetic condition affecting small intestine, characterised by prolamine (protein found in gluten) sensitivity leading to villous atrophy and malabsorption

Any age - young/old

Question 2

Signs and symptoms of coeliac disease?

Answer 2

Symptoms:
Abdominal pain
N+V
Diarrhoea
Weight loss

Signs:
Weight loss/Failure To Thrive
Anaemia
Pallor
Abdominal distension
Steatorrhoea
Dermatitis herpetiformis

Question 3

What is dermatitis herpetiformis?

Answer 3

Purpuric papulovesicular lesions over buttocks, trunk and extensors

Question 4

What are the findings on OGD suggestive of coeliac disease?

Answer 4

Villous atrophy

Crypt hyperplasia

Increased intraepithelial T-lymphocytes

Question 5

Gold standard diagnosis of coeliac disease?

Answer 5

OGD