What 3 sources are gonads derived from?
- Mesothelium: (mesodermal epithelium) lining posterior abdominal wall
- Underlying mesenchyme: (embryonic connective tissue)
- Primordial Germ Cells: (earliest undifferentiated sex cells)
What is an indifferent gonad?
Primordial organ before differentiation into gonads
At what week are initial stages of gonadal development?
What produces the gonadal ridge?
Proliferation of mesothelium and underlying mesenchymal cells
What is the permanent kidney primordium?
Thickened area of mesothelium developing on medial side of mesonephros
Indifferent gonad consists of
Cortex differentiates into
Ovary, medulla regresses
Medulla differentiates into
Testes, cortex regresses
What do the Gonadal cords become in males at wk5?
Seminiferous cords (Primordia of the seminiferous tubules)
What do the parts of the gonadal cords that enter the medulla become in wk 5?
What 2 kinds of cells are made during wk 5 male sexual differentiation in gonads?
Spermatogonia And Sertoli Cells
What are spermatogonia derived from?
Primordial germ cells
What are sertoli cells derived from?
What are follicular cells derived from?
Surface epithelium of ovary
Which duct is the paramesonephric duct?
Which duct is the mesonephric duct?
In male embryo, SRY turns on expression of...
Testis determining factor
What cells make Anti-Mulerian Hormone?
Wolffian duct becomes the ...
Conductive ducts: epididymis, vas deferens, seminal vesicles
Where are PCGs initially located?
Amongst endodermal cells of yolk sac, near origin of allantois
PCGs migrate along...
Dorsal mesentery of hindgut to gonadal ridges
What is happenening to PGCs during 6th week of development?
PGCs enter underlying mesenchyme and incorporated into gonadal cords.
The Homologous Genital tubercle differnetiates into:
Penis (male), Clitoris (female)
The urethral folds develop into the:
Penile urethra (male), labia minora (female)
The urethral groove deveops into the:
Disappears in males, Vestibule (Females)
The labioscrotal swelling develops into the:
Scrotum (male), Labia majora (female)
What directs direction of descent of ovaries and testes?
Why does the testes descend into the scrotum?
Temperature regulation for sperm production
What happens to the gubernaculum in males?
Shrinks into a small structure attached to the base of the scrotum
What happens to the gubernaculum in women?
Gives rise to the ovarian and round ligaments, the latter is attached to the labia majora