COMPASS Study Flashcards
What was the purpose of COMPASS
To provide additional independent validation of Corus CAD in a real-world setting.
How many patients were enrolled in the analysis cohort?
431
When was the study published?
April 2013
How many sites were enrolling?
19
When was Corus CAD introduced into the patient pathway?
Corus CAD was done at the same time (just before) as stress MPI. Investigators were blinded to results
Who is the Principal Investigator?
Gregory Thomas, MD, MPH University of California, Irvine
What was the sensitivity of MPI in this study?
What was the sensitivity of Corus CAD?
MPI: 27% Site read, 36% Core lab
Corus CAD: 89%
What was the NPV for MPI?
88%
What was the NPV for Corus CAD?
96%
What was the NPV for MACE and revascularization @ 6 months?
<99%
What journal was this published in?
Circulation-CV Genetics
How many had a MACE/revascularizations? Total? Low score?
27/28 patients with MACE had a score >15
What was the ROC for CorusCAD?
ROC: 0.79
What was the ROC for MPI in this study?
ROC: 0.63
What was the overall prevalence of obstructive CAD?
15%
